Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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ADU46918.1Transcriptional regulator, CadC; COGs: COG3710 DNA-binding winged-HTH domains; InterPro IPR001867: IPR000073; KEGG: msm:MSMEG_3856 transcriptional regulator, CadC; PFAM: transcriptional regulator domain-containing protein; alpha/beta hydrolase fold; SPTR: Transcriptional regulator, CadC; PFAM: Transcriptional regulatory protein, C terminal; alpha/beta hydrolase fold. (411 aa)    
Predicted Functional Partners:
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.765
ADU46919.1
FAD dependent oxidoreductase; COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR006076: IPR003042; KEGG: sen:SACE_3335 monooxygenase, FAD-binding; PFAM: FAD dependent oxidoreductase; SPTR: Monooxygenase, FAD-binding; PFAM: FAD binding domain.
  
  
 0.602
ADU46920.1
OsmC family protein; COGs: COG1765 redox protein regulator of disulfide bond formation; InterPro IPR003718; KEGG: ade:Adeh_2254 OsmC-like protein; PFAM: OsmC family protein; SPTR: OsmC-like protein; PFAM: OsmC-like protein.
       0.594
sigA
RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.575
ADU48211.1
KEGG: sro:Sros_6098 hypothetical protein; SPTR: Putative uncharacterized protein.
   
   0.526
argS
COGs: COG0018 Arginyl-tRNA synthetase; InterProIPR005148: IPR015945: IPR008909: IPR001278: IPR 001412; KEGG: tfu:Tfu_0269 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; arginyl tRNA synthetase domain protein; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; SPTR: Arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase.
       0.498
ADU46916.1
COGs: COG2132 Putative multicopper oxidase; InterPro IPR017909: IPR011707: IPR011706: IPR002355; KEGG: sli:Slin_6866 bilirubin oxidase; PFAM: multicopper oxidase type 3; multicopper oxidase type 2; SPTR: Bilirubin oxidase; PFAM: Multicopper oxidase.
       0.484
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.454
ADU47356.1
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: nca:Noca_1837 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase.
  
 
  0.432
ADU46646.1
COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR006367: IPR006366; KEGG: aau:AAur_3076 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase, C-terminal:Siroheme synthase,N-terminal; TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase, N-terminal domain.
     
 0.423
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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