close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU47005.1Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (374 aa)    
Predicted Functional Partners:
ADU47943.1
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: kfl:Kfla_5445 gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltranspeptidase; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
    
 0.938
gshB
COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR011761: IPR004218; KEGG: kse:Ksed_05120 glutathione synthetase; PFAM: glutathione synthetase ATP-binding; PRIAM: Glutathione synthase; SPTR: Glutathione synthetase; PFAM: Prokaryotic glutathione synthetase, N-terminal domain; Prokaryotic glutathione synthetase, ATP-grasp domain; TIGRFAM: glutathione synthetase, prokaryotic; Belongs to the prokaryotic GSH synthase family.
    
 0.913
ADU47267.1
Membrane alanyl aminopeptidase; COGs: COG0308 Aminopeptidase N; InterPro IPR014782: IPR012778; KEGG: kse:Ksed_21360 aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; SPTR: Putative aminopeptidase; TIGRFAM: aminopeptidase N; PFAM: Peptidase family M1; Domain of unknown function (DUF3358); TIGRFAM: aminopeptidase N, Streptomyces lividans type.
     
 0.904
ADU47877.1
Membrane alanyl aminopeptidase; COGs: COG0308 Aminopeptidase N; InterPro IPR012778: IPR014782: IPR005829; KEGG: kse:Ksed_09020 aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; PRIAM: Membrane alanyl aminopeptidase; SPTR: Aminopeptidase N; TIGRFAM: aminopeptidase N; PFAM: Domain of unknown function (DUF3358); Peptidase family M1; TIGRFAM: aminopeptidase N, Streptomyces lividans type.
     
 0.904
pxpA
LamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
     
  0.900
pepA
Peptidase M17 leucyl aminopeptidase domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
     
  0.900
ADU47674.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160: IPR005931; KEGG: nca:Noca_1220 delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Delta-1-pyrroline-5-carboxylate dehydrogenase 1; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 1.
   
 
  0.805
ADU48993.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR005931: IPR015590: IPR016160; KEGG: kse:Ksed_08740 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; PFAM: Aldehyde Dehydrogenase; SPTR: Delta-1-pyrroline-5-carboxylate dehydrogenase 1; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 1.
   
 
  0.805
ADU46858.1
COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR005856: IPR005859: IPR001216; KEGG: bcv:Bcav_2609 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
     
  0.800
ADU48014.1
Aminotransferase class I and II; COGs: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; InterPro IPR004839; KEGG: mmi:MMAR_3453 aminotransferase; PFAM: aminotransferase class I and II; SPTR: Putative transferase; PFAM: Aminotransferase class I and II.
     
  0.800
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.