STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU47008.1RNA polymerase, sigma 28 subunit, Sig B/F/G subfamily; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit; InterProIPR007627: IPR007624: IPR007630: IPR000943: IPR 014322: IPR014284; KEGG: nca:Noca_1393 sigma-70 region 4 domain-containing protein; PFAM: sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; sigma-70 region 4 domain protein; SPTR: Sigma-70 region 4 domain protein; TIGRFAM: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 region 2; TIGRFA [...] (282 aa)    
Predicted Functional Partners:
ADU47303.1
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932: IPR007895: IPR010822: IPR003594; KEGG: gob:Gobs_0116 multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E; MASE1 domain protein; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E (SpoIIE); MASE1.
 
 
 0.984
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.900
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.885
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.882
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.881
ADU49393.1
ATP-binding region ATPase domain protein; InterPro IPR003018: IPR003594: IPR018247; KEGG: cai:Caci_4163 putative PAS/PAC sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; SPTR: PAS/PAC sensor hybrid histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
 
 0.796
ADU49002.1
SAF domain protein; InterPro IPR013974; KEGG: cfl:Cfla_2320 hypothetical protein; PFAM: SAF domain protein; SPTR: Putative uncharacterized protein.
  
  
 0.706
ADU47078.1
Anti-sigma-factor antagonist; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR002645: IPR003658; KEGG: kfl:Kfla_0571 anti-sigma-factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; anti-sigma F factor antagonist.
 
 
 0.663
ADU46986.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR000014: IPR000700: IPR 005561: IPR013656: IPR003661: IPR003594: IPR013767: IPR004358; KEGG: ami:Amir_3954 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; response regulator receiver; PAS fold domain protein; ANTAR domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Multi [...]
  
  
 0.624
ADU49309.1
Response regulator receiver protein; COGs: COG0492 Thioredoxin reductase; InterPro IPR001789: IPR000103: IPR013027; KEGG: rer:RER_40230 two-component system thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Response regulator receiver domain.
  
  
 0.581
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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