STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU47009.1Transcriptional regulator, AraC family; COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR018060: IPR000005; KEGG: mkm:Mkms_4430 AraC family transcriptional regulator; PFAM: helix-turn-helix- domain containing protein AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: AraC family transcriptional regulator; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family. (348 aa)    
Predicted Functional Partners:
ADU47946.1
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: gob:Gobs_0866 silent information regulator protein Sir2; PFAM: Silent information regulator protein Sir2; SPTR: Putative SIR2-like regulatory protein; PFAM: Sir2 family.
 
  
 0.595
ADU49281.1
Transcriptional regulator, LysR family; COGs: COG0583 Transcriptional regulator; InterPro IPR000847: IPR017685; KEGG: xce:Xcel_2242 transcriptional regulator, LysR family; PFAM: regulatory protein LysR; SPTR: Transcriptional regulator, LysR family; TIGRFAM: transcriptional regulator, ArgP family; PFAM: Bacterial regulatory helix-turn-helix protein, lysR family; LysR substrate binding domain; TIGRFAM: transcriptional regulator, ArgP family.
  
  
 0.570
ADU46903.1
Putative transcriptional regulator, GntR family; COGs: COG2188 Transcriptional regulators; InterPro IPR011663; KEGG: nda:Ndas_2625 transcriptional regulator, GntR family; PFAM: UbiC transcription regulator-associated domain-containing protein; SPTR: Transcriptional regulator, GntR family; manually curated; PFAM: UTRA domain.
   
  
 0.553
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.514
ADU46986.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR000014: IPR000700: IPR 005561: IPR013656: IPR003661: IPR003594: IPR013767: IPR004358; KEGG: ami:Amir_3954 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; response regulator receiver; PAS fold domain protein; ANTAR domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Multi [...]
  
  
 0.505
ADU47008.1
RNA polymerase, sigma 28 subunit, Sig B/F/G subfamily; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit; InterProIPR007627: IPR007624: IPR007630: IPR000943: IPR 014322: IPR014284; KEGG: nca:Noca_1393 sigma-70 region 4 domain-containing protein; PFAM: sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; sigma-70 region 4 domain protein; SPTR: Sigma-70 region 4 domain protein; TIGRFAM: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 region 2; TIGRFA [...]
     
 0.433
ADU49743.1
PTS system D-fructose-specific IIABC components (F1P-forming), Frc family; COGs: COG1299 Phosphotransferase system fructose-specific IIC component; InterProIPR002178: IPR013011: IPR013014: IPR004715: IPR 003353: IPR006327: IPR003352; KEGG: sco:SCO3196 fructose-specific permease; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; phosphotransferase system EIIC; SPTR: Fructose-specific permease; TIGRFAM: PTS system, fructose subfamily, IIC subunit; PTS system, fructose subfamily, IIA subunit; PTS system, fructose-specific, IIB subunnit; PFAM: Phosphotransferase s [...]
   
 
 0.418
ADU47010.1
Domain of unknown function DUF1905; InterPro IPR015018; KEGG: bcv:Bcav_4116 hypothetical protein; PFAM: Domain of unknown function DUF1905; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1905).
       0.413
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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