STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folECOGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602: IPR001474: IPR018234; KEGG: ske:Sked_32080 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (190 aa)    
Predicted Functional Partners:
ADU47148.1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.999
ADU47147.1
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.994
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.960
ribA-2
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family.
  
 
 0.950
ADU47551.1
Hypothetical protein; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; KEGG: tcu:Tcur_2746 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: 6-pyruvoyl tetrahydropterin synthase.
  
 
 0.923
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
   
 
 0.913
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
  0.908
ADU46860.1
COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489: IPR006390; KEGG: pfr:PFREUD_02120 dihydropteroate synthase ((2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl- diphosphate:4-am inobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase); PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Dihydropteroate synthase ((2-amino-4-hydroxy-7, 8-dihydropteridin-6-yl)methyl-diphosphate:4- aminobenzoate 2-amino-4-hydroxydihydropteridine-6- methenyltransferase); TIGRFAM: dihydropteroate synthase; manually curated; PFAM: Pterin binding enzyme; TIGRFAM: [...]
  
 0.907
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.840
ADU48721.1
FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645: IPR018109: IPR013221: IPR004101; KEGG: kse:Ksed_09160 folylpolyglutamate synthase/dihydrofolate synthase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: Putative folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase.
  
  
 0.829
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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