STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU47155.1Putative oxidoreductase/dehydrogenase, Rossmann-like domain; COGs: COG5495 conserved hypothetical protein; InterPro IPR019665: IPR018931; KEGG: tcu:Tcur_4488 NADP oxidoreductase coenzyme F420-dependent; PFAM: Putative oxidoreductase/dehydrogenase, Rossmann-like domain; Domain of unknown function DUF2520; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF2520); Rossmann-like domain. (302 aa)    
Predicted Functional Partners:
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
   
 0.988
panD
L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
   
 0.807
ADU47154.1
Protein of unknown function DUF185; COGs: COG1565 conserved hypothetical protein; InterPro IPR003788; KEGG: sgr:SGR_4103 hypothetical protein; PFAM: protein of unknown function DUF185; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized ACR, COG1565.
       0.669
panB
Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
 
   
 0.650
ADU47153.1
Copper resistance protein CopC; COGs: COG2372 conserved hypothetical protein homolog of Cu resistance protein CopC; InterPro IPR007348; KEGG: aau:AAur_0407 copper resistance protein CopC; PFAM: copper resistance protein CopC; SPTR: Putative copper resistance protein, CopC family; PFAM: Copper resistance protein CopC.
 
     0.637
nuoD
NADH dehydrogenase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family.
       0.465
ADU47151.1
KEGG: mul:MUL_0582 hypothetical protein; SPTR: Conserved protein.
       0.455
ADU47148.1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
       0.449
ADU47179.1
COGs: COG1246 N-acetylglutamate synthase and related acetyltransferase; InterPro IPR000182; KEGG: lxx:Lxx21330 N-acetylglutamate synthase; PFAM: GCN5-related N-acetyltransferase; SPTR: Acetyltransferase; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family.
 
     0.407
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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