STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
kuDNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (336 aa)    
Predicted Functional Partners:
ADU47172.1
DNA polymerase LigD, polymerase domain protein; COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR002755: IPR014145; KEGG: nca:Noca_1237 ATP dependent DNA ligase; PFAM: DNA primase small subunit; SPTR: DNA ligase; TIGRFAM: DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA polymerase LigD, polymerase domain.
 
  
 0.961
ADU47171.1
DNA polymerase LigD, ligase domain protein; COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR012310: IPR014146: IPR016059; KEGG: cfl:Cfla_1903 DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase; SPTR: DNA ligase; TIGRFAM: DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain.
 
  
 0.942
ADU50001.1
COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR012310: IPR012309; KEGG: nml:Namu_0826 ATP-dependent DNA ligase; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; SPTR: DNA ligase; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region.
 
  
 0.930
ADU48409.1
DNA polymerase LigD, polymerase domain protein; COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR002755: IPR014145; KEGG: amd:AMED_4612 ATP-dependent DNA ligase; PFAM: DNA primase small subunit; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: Eukaryotic and archaeal DNA primase small subunit; TIGRFAM: DNA ligase D; DNA polymerase LigD, polymerase domain.
 
  
 0.882
ADU50000.1
COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR002755; KEGG: kse:Ksed_15620 DNA polymerase LigD, polymerase domain; PFAM: DNA primase small subunit; SPTR: DNA ligase; TIGRFAM: DNA polymerase LigD, polymerase domain.
 
  
 0.882
ADU49698.1
COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR012310: IPR000977: IPR012309; KEGG: nca:Noca_2845 ATP-dependent DNA ligase; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; PRIAM: DNA ligase (ATP); SPTR: Probable DNA ligase; TIGRFAM: DNA ligase I, ATP-dependent Dnl1; PFAM: ATP dependent DNA ligase domain; DNA ligase N terminus; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA ligase I, ATP-dependent (dnl1); Belongs to the ATP-dependent DNA ligase family.
 
  
 0.872
ADU46988.1
COGs: COG3569 Topoisomerase IB; InterPro IPR001631; KEGG: amd:AMED_4291 DNA topoisomerase IB; SPTR: Putative uncharacterized protein; PFAM: Eukaryotic DNA topoisomerase I, catalytic core.
 
    0.555
ADU47169.1
COGs: COG0427 Acetyl-CoA hydrolase; KEGG: nca:Noca_1803 acetyl-CoA hydrolase/transferase; SPTR: Acetyl-CoA hydrolase/transferase.
       0.497
ADU47578.1
COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212: IPR014016: IPR014017: IPR005751; KEGG: kse:Ksed_07720 ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; SPTR: Putative ATP-dependent DNA helicase II; TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA.
      
 0.463
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
      
 0.463
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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