Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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[Homology]
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disAProtein of unknown function DUF147; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. (359 aa)    
Predicted Functional Partners:
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.960
ADU47177.1
COGs: COG1194 A/G-specific DNA glycosylase; InterPro IPR003265: IPR003651: IPR004036; KEGG: tcu:Tcur_4471 HhH-GPD family protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; iron-sulfur cluster loop; SPTR: Putative adenine glycosylase; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif; TIGRFAM: A/G-specific adenine glycosylase.
       0.824
ADU46961.1
Hypothetical protein; InterPro IPR014447; KEGG: xce:Xcel_0235 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.675
ADU47716.1
Phosphoesterase HXTX; COGs: COG1514 2'-5' RNA ligase; InterPro IPR014051; KEGG: kfl:Kfla_1321 phosphoesterase HXTX; PFAM: Phosphoesterase HXTX; SPTR: Putative secreted protein; PFAM: 2',5' RNA ligase family.
  
     0.591
ADU49063.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1172 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: Putative DNA helicase; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily.
   
    0.589
ADU49064.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1171 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: Putative ATP-dependent DNA helicase; PFAM: UvrD/REP helicase.
   
    0.589
ADU48334.1
Protein of unknown function DUF1290; COGs: COG3856 conserved hypothetical protein (small basic protein); InterPro IPR009709; KEGG: ske:Sked_18240 uncharacterized conserved protein (small basic protein); PFAM: protein of unknown function DUF1290; SPTR: Putative membrane protein; PFAM: Protein of unknown function (DUF1290).
  
     0.509
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
    0.476
ADU46622.1
Protein of unknown function DUF881; COGs: COG3879 conserved hypothetical protein; InterPro IPR010273; KEGG: kra:Krad_0026 protein of unknown function DUF881; PFAM: protein of unknown function DUF881; SPTR: Putative uncharacterized protein; PFAM: Bacterial protein of unknown function (DUF881).
  
     0.465
ADU48335.1
Protein of unknown function DUF881; COGs: COG3879 conserved hypothetical protein; InterPro IPR010273; KEGG: sco:SCO1387 membrane associated protein; PFAM: protein of unknown function DUF881; SPTR: Putative uncharacterized protein; PFAM: Bacterial protein of unknown function (DUF881).
  
     0.432
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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