STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (316 aa)    
Predicted Functional Partners:
ADU47205.1
Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR000878: IPR003754: IPR003043; KEGG: kra:Krad_0619 uroporphyrin-III C/tetrapyrrole (corrin/porphyrin) methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD.
 0.999
ADU47206.1
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: mpa:MAP4005 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.999
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.998
ADU47334.1
COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR006366; KEGG: nml:Namu_0162 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase.
  
 0.987
ADU46646.1
COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR006367: IPR006366; KEGG: aau:AAur_3076 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase, C-terminal:Siroheme synthase,N-terminal; TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase, N-terminal domain.
  
 0.985
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.982
hemL
COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: kra:Krad_0626 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde aminotransferase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
 
  
 0.943
ADU50056.1
Aminotransferase class-III; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814; KEGG: fal:FRAAL6024 putative glutamate-1-semialdehyde aminotransferase (aminomutase), PLP-dependent; PFAM: aminotransferase class-III; SPTR: Putative glutamate-1-semialdehyde aminotransferase (Aminomutase), PLP-dependent; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.889
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.840
rex
CoA-binding domain protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
       0.830
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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