Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
ADU47277.1Helicase domain protein; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR014001: IPR001650: IPR014021: IPR006935; KEGG: ske:Sked_31430 DNA/RNA helicase, superfamily II; PFAM: helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein; SPTR: Putative ATP-dependent DNA helicase; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit. (550 aa)    
Predicted Functional Partners:
ADU48668.1
Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR014001: IPR006555: IPR014013; KEGG: kse:Ksed_17400 DNA helicase, Rad3; SMART: helicase c2; DEAD-like helicase; SPTR: Putative ATP-dependent helicase; PFAM: DEAD/DEAH box helicase.
   
 0.849
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  0.829
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
  0.822
ADU47279.1
KEGG: kra:Krad_3610 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.792
ADU50096.1
COGs: COG1260 Myo-inositol-1-phosphate synthase; InterPro IPR002587: IPR013021: IPR017815; KEGG: nca:Noca_4678 myo-inositol-1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase GAPDH domain protein; SPTR: Myo-inositol-1-phosphate synthase; TIGRFAM: inositol 1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; TIGRFAM: inositol 1-phosphate synthase, Actinobacterial type.
    
   0.690
ADU50023.1
ERCC4 domain protein; InterPro IPR006166; KEGG: nca:Noca_3806 ERCC4 domain-containing protein; PFAM: ERCC4 domain protein; SPTR: ERCC4 domain protein; PFAM: Lsr2.
   
 0.635
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 0.629
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.624
ADU48296.1
COGs: COG0258 5'-3' exonuclease (including N-terminal domain of PolI); InterPro IPR002421: IPR008918: IPR020046: IPR020047; KEGG: cfl:Cfla_0590 5'-3' exonuclease, N-terminal resolvase-like domain protein; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: Putative 5'-3' exonuclease; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain.
    
 0.587
ADU47278.1
hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: kse:Ksed_21580 hydroxymethylglutaryl-CoA lyase; PFAM: pyruvate carboxyltransferase; SPTR: Putative hydroxymethylglutaryl-CoA lyase; PFAM: HMGL-like.
       0.554
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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