STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
serCPhosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (385 aa)    
Predicted Functional Partners:
ADU48864.1
COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006236: IPR006140: IPR006139: IPR002912; KEGG: cai:Caci_7791 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; PRIAM: Phosphoglycerate dehydrogenase; SPTR: Probable D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hyd [...]
 
 0.988
ADU48237.1
COGs: COG0560 Phosphoserine phosphatase; InterProIPR002912: IPR005834: IPR004469: IPR006383: IPR 006385; KEGG: kfl:Kfla_3704 phosphoserine phosphatase SerB; PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein; PRIAM: Phosphoserine phosphatase; SPTR: Putative phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; manually curated; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR0149 [...]
 
 
 0.971
ADU48959.1
L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
   
 0.944
ADU46858.1
COGs: COG0031 Cysteine synthase; InterPro IPR001926: IPR005856: IPR005859: IPR001216; KEGG: bcv:Bcav_2609 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.917
ADU48876.1
COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006140; KEGG: cai:Caci_6823 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; SPTR: Putative dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain.
  
 
 0.828
pheA
COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR002912: IPR018528; KEGG: ach:Achl_0282 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; PFAM: Prephenate dehydratase.
  
  
 0.714
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
  
 0.698
ADU47292.1
COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR019810; KEGG: sma:SAV_3859 citrate synthase 2; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.697
ADU49554.1
HAD-superfamily subfamily IB hydrolase, TIGR01490; COGs: COG0560 Phosphoserine phosphatase; InterPro IPR005834: IPR006383: IPR006385; KEGG: cwo:Cwoe_4644 HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: HAD-superfamily subfamily IB hydrolase, TIGR01490; TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like.
 
  
 0.648
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
   
  
 0.620
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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