Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADU47299.1Iron (metal) dependent repressor, DtxR family; COGs: COG1321 Mn-dependent transcriptional regulator protein; InterPro IPR001808: IPR001367: IPR007167; KEGG: kse:Ksed_24030 Mn-dependent transcriptional regulator; PFAM: iron dependent repressor; FeoA family protein; SMART: iron dependent repressor; regulatory protein Crp; SPTR: Iron-dependent repressor, DxtR metalloregulatory family protein; PFAM: Iron dependent repressor, metal binding and dimerisation domain; Iron dependent repressor, N-terminal DNA binding domain. (241 aa)    
Predicted Functional Partners:
ADU47298.1
Major facilitator superfamily MFS_1; COGs: COG2814 Arabinose efflux permease; InterPro IPR011701; KEGG: kfl:Kfla_6159 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Probable transporter; PFAM: Major Facilitator Superfamily.
     
 0.797
ADU48580.1
KEGG: aau:AAur_2439 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3145).
  
     0.582
ADU47300.1
NLP/P60 protein; COGs: COG0791 Cell wall-associated hydrolase (invasion-associated protein); InterPro IPR000064; KEGG: kra:Krad_4554 NLP/P60 protein; PFAM: NLP/P60 protein; SPTR: Protein containing cell-wall hydrolase domain; PFAM: NlpC/P60 family.
     
 0.555
ADU47827.1
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935: IPR014001: IPR014021; KEGG: kse:Ksed_10520 DNA/RNA helicase, superfamily II; PFAM: type III restriction protein res subunit; SMART: DEAD-like helicase; SPTR: Putative uncharacterized protein; manually curated; PFAM: Type III restriction enzyme, res subunit.
 
     0.529
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
      
 0.495
ADU48634.1
Zinc uptake regulator, Fur family; COGs: COG0735 Fe2+/Zn2+ uptake regulation protein; InterPro IPR002481; KEGG: mmi:MMAR_3669 zinc uptake regulation protein Zur; PFAM: ferric-uptake regulator; SPTR: Zinc uptake regulation protein Zur; PFAM: Ferric uptake regulator family; Belongs to the Fur family.
  
  
 0.486
ADU48530.1
Domain of unknown function DUF1731; COGs: COG1090 nucleoside-diphosphate sugar epimerase; InterPro IPR001509: IPR013549: IPR010099; KEGG: bcv:Bcav_1861 domain of unknown function DUF1731; PFAM: domain of unknown function DUF1731; NAD-dependent epimerase/dehydratase; SPTR: Putative NAD dependent epimerase/dehydratase family protein; PFAM: NAD dependent epimerase/dehydratase family; Domain of unknown function (DUF1731); TIGRFAM: conserved hypothetical protein TIGR01777.
   
    0.482
sigA
RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
  
 0.472
ADU48493.1
Cytochrome-c oxidase; COGs: COG1845 Heme/copper-type cytochrome/quinol oxidase subunit 3; InterPro IPR000298; KEGG: kse:Ksed_16180 heme/copper-type cytochrome/quinol oxidase, subunit 3; PFAM: cytochrome c oxidase subunit III; PRIAM: Cytochrome-c oxidase; SPTR: Heme/copper-type cytochrome/quinol oxidase, subunit 3; manually curated; PFAM: Cytochrome c oxidase subunit III.
      
 0.472
ADU49784.1
Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family.
      
 0.458
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.