STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU47336.1cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: svi:Svir_17750 cob(I)yrinic acid a,c-diamide adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: Cob(I)yrinic acid a,c-diamide adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. (203 aa)    
Predicted Functional Partners:
cobB
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
 
 0.997
ADU47330.1
Cobaltochelatase CobN subunit; COGs: COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatase; InterPro IPR003672: IPR011953; KEGG: nml:Namu_0145 cobaltochelatase subunit CobN; PFAM: CobN/magnesium chelatase; PRIAM: Cobaltochelatase; SPTR: Cobaltochelatase; TIGRFAM: cobaltochelatase, CobN subunit; PFAM: CobN/Magnesium Chelatase; TIGRFAM: cobaltochelatase, CobN subunit.
 
  
 0.991
ADU48522.1
COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: amd:AMED_7046 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; SPTR: Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase.
 
  
 0.991
cobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
 
 0.989
cobQ
Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.987
cobD
Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.985
ADU47337.1
Protoporphyrin IX magnesium-chelatase; COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR003593: IPR002035: IPR011704; KEGG: nml:Namu_0159 magnesium chelatase; PFAM: von Willebrand factor type A; ATPase associated with various cellular activities AAA_5; PRIAM: Magnesium chelatase; SMART: von Willebrand factor type A; AAA ATPase; SPTR: Magnesium chelatase; PFAM: Magnesium chelatase, subunit ChlI; von Willebrand factor type A domain.
 
   
 0.941
ADU47338.1
precorrin-6Y C5,15-methyltransferase (decarboxylating); COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR000878: IPR006365: IPR012818: IPR014008; KEGG: nml:Namu_0158 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: Precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiT subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (decarboxylating), C [...]
 
   
 0.934
ADU48935.1
ATP:cob(I)alamin adenosyltransferase; COGs: COG2096 conserved hypothetical protein; InterPro IPR017858: IPR002779; KEGG: kse:Ksed_18150 ATP:cob(I)alamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase.
    
 0.928
ADU47339.1
COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878: IPR003043; KEGG: tfu:Tfu_0315 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Putative methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family.
 
   
 0.913
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.