| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADU47591.1 | ADU47596.1 | Intca_1068 | Intca_1075 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | 0.786 |
| ADU47591.1 | ADU47597.1 | Intca_1068 | Intca_1076 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040: IPR002821; KEGG: nca:Noca_1496 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) A 2; PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region. | 0.714 |
| ADU47591.1 | ADU47603.1 | Intca_1068 | Intca_1082 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | Carbon monoxide dehydrogenase subunit G; COGs: COG3427 conserved hypothetical protein; InterPro IPR010419; KEGG: rop:ROP_32810 hypothetical protein; PFAM: carbon monoxide dehydrogenase subunit G; SPTR: Putative uncharacterized protein; PFAM: Carbon monoxide dehydrogenase subunit G (CoxG). | 0.734 |
| ADU47591.1 | ADU47604.1 | Intca_1068 | Intca_1083 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; COGs: COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL homologs; InterPro IPR000674: IPR008274; KEGG: svi:Svir_20920 xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; SPTR: Probable dehydrogenase/oxidase; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain. | 0.603 |
| ADU47591.1 | ADU47606.1 | Intca_1068 | Intca_1085 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | COGs: COG2233 Xanthine/uracil permease; InterPro IPR006043: IPR006042; KEGG: cai:Caci_1870 uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; SPTR: Putative uracyl permease; TIGRFAM: uracil-xanthine permease; PFAM: Permease family; TIGRFAM: uracil-xanthine permease. | 0.609 |
| ADU47591.1 | ADU47607.1 | Intca_1068 | Intca_1086 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | Transcriptional regulator, CdaR; COGs: COG3835 Sugar diacid utilization regulator; KEGG: tcu:Tcur_2969 transcriptional regulator, CdaR; SPTR: Transcriptional regulator. | 0.777 |
| ADU47591.1 | ADU47608.1 | Intca_1068 | Intca_1087 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | KEGG: tbi:Tbis_2233 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2877). | 0.713 |
| ADU47591.1 | ADU47609.1 | Intca_1068 | Intca_1088 | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | Protein of unknown function DUF1116; COGs: COG0074 Succinyl-CoA synthetase alpha subunit; InterPro IPR009499; KEGG: nml:Namu_5358 protein of unknown function DUF1116; PFAM: protein of unknown function DUF1116; SPTR: Putative uncharacterized protein; PFAM: CoA binding domain; CoA-ligase; Protein of unknown function (DUF1116). | 0.754 |
| ADU47596.1 | ADU47591.1 | Intca_1075 | Intca_1068 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | 0.786 |
| ADU47596.1 | ADU47597.1 | Intca_1075 | Intca_1076 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040: IPR002821; KEGG: nca:Noca_1496 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) A 2; PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region. | 0.999 |
| ADU47596.1 | ADU47603.1 | Intca_1075 | Intca_1082 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | Carbon monoxide dehydrogenase subunit G; COGs: COG3427 conserved hypothetical protein; InterPro IPR010419; KEGG: rop:ROP_32810 hypothetical protein; PFAM: carbon monoxide dehydrogenase subunit G; SPTR: Putative uncharacterized protein; PFAM: Carbon monoxide dehydrogenase subunit G (CoxG). | 0.668 |
| ADU47596.1 | ADU47604.1 | Intca_1075 | Intca_1083 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; COGs: COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL homologs; InterPro IPR000674: IPR008274; KEGG: svi:Svir_20920 xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; SPTR: Probable dehydrogenase/oxidase; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain. | 0.430 |
| ADU47596.1 | ADU47607.1 | Intca_1075 | Intca_1086 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | Transcriptional regulator, CdaR; COGs: COG3835 Sugar diacid utilization regulator; KEGG: tcu:Tcur_2969 transcriptional regulator, CdaR; SPTR: Transcriptional regulator. | 0.729 |
| ADU47596.1 | ADU47608.1 | Intca_1075 | Intca_1087 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | KEGG: tbi:Tbis_2233 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2877). | 0.523 |
| ADU47596.1 | ADU47609.1 | Intca_1075 | Intca_1088 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | Protein of unknown function DUF1116; COGs: COG0074 Succinyl-CoA synthetase alpha subunit; InterPro IPR009499; KEGG: nml:Namu_5358 protein of unknown function DUF1116; PFAM: protein of unknown function DUF1116; SPTR: Putative uncharacterized protein; PFAM: CoA binding domain; CoA-ligase; Protein of unknown function (DUF1116). | 0.547 |
| ADU47597.1 | ADU47591.1 | Intca_1076 | Intca_1068 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040: IPR002821; KEGG: nca:Noca_1496 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) A 2; PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region. | Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. | 0.714 |
| ADU47597.1 | ADU47596.1 | Intca_1076 | Intca_1075 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040: IPR002821; KEGG: nca:Noca_1496 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) A 2; PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region. | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: cai:Caci_1877 hydantoinase B/oxoprolinase; PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) B 2; PFAM: Hydantoinase B/oxoprolinase. | 0.999 |
| ADU47597.1 | ADU47603.1 | Intca_1076 | Intca_1082 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040: IPR002821; KEGG: nca:Noca_1496 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) A 2; PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region. | Carbon monoxide dehydrogenase subunit G; COGs: COG3427 conserved hypothetical protein; InterPro IPR010419; KEGG: rop:ROP_32810 hypothetical protein; PFAM: carbon monoxide dehydrogenase subunit G; SPTR: Putative uncharacterized protein; PFAM: Carbon monoxide dehydrogenase subunit G (CoxG). | 0.522 |
| ADU47597.1 | ADU47607.1 | Intca_1076 | Intca_1086 | 5-oxoprolinase (ATP-hydrolyzing); COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040: IPR002821; KEGG: nca:Noca_1496 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: N-methylhydantoinase (ATP-hydrolyzing) A 2; PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region. | Transcriptional regulator, CdaR; COGs: COG3835 Sugar diacid utilization regulator; KEGG: tcu:Tcur_2969 transcriptional regulator, CdaR; SPTR: Transcriptional regulator. | 0.586 |
| ADU47602.1 | ADU47603.1 | Intca_1081 | Intca_1082 | COGs: COG0388 amidohydrolase; InterPro IPR003010; KEGG: cai:Caci_1875 nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; SPTR: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; PFAM: Carbon-nitrogen hydrolase. | Carbon monoxide dehydrogenase subunit G; COGs: COG3427 conserved hypothetical protein; InterPro IPR010419; KEGG: rop:ROP_32810 hypothetical protein; PFAM: carbon monoxide dehydrogenase subunit G; SPTR: Putative uncharacterized protein; PFAM: Carbon monoxide dehydrogenase subunit G (CoxG). | 0.811 |