STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADU47615.14-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (386 aa)    
Predicted Functional Partners:
ADU47616.1
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
 0.999
ADU47617.1
COGs: COG3971 2-keto-4-pentenoate hydratase; InterPro IPR002529; KEGG: amd:AMED_8623 2-keto-4-pentenoate hydratase; PFAM: fumarylacetoacetate (FAA) hydrolase; PRIAM: 2-oxopent-4-enoate hydratase; SPTR: 2-oxopent-4-enoate hydratase; PFAM: Fumarylacetoacetate (FAA) hydrolase family; TIGRFAM: 2-oxopent-4-enoate hydratase.
 
 
 0.996
ADU47614.1
4-oxalocrotonate decarboxylase; COGs: COG3971 2-keto-4-pentenoate hydratase; InterPro IPR002529; KEGG: mjl:Mjls_4208 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; PRIAM: 4-oxalocrotonate decarboxylase; SPTR: 4-oxalocrotonate decarboxylase; PFAM: Fumarylacetoacetate (FAA) hydrolase family.
 
  
 0.970
ADU47611.1
2-hydroxymuconate semialdehyde hydrolase; COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073; KEGG: tcu:Tcur_0531 alpha/beta hydrolase fold protein; PFAM: alpha/beta hydrolase fold; SPTR: 2-hydroxymuconic semialdehyde hydrolase; PFAM: alpha/beta hydrolase fold.
 
 
  0.929
ADU47613.1
4-oxalocrotonate tautomerase family enzyme; InterPro IPR004370: IPR018191; KEGG: nfa:nfa30440 putative isomerase; PFAM: 4-oxalocrotonate tautomerase; SPTR: Putative isomerase; TIGRFAM: 4-oxalocrotonate tautomerase family enzyme; PFAM: Tautomerase enzyme; TIGRFAM: 4-oxalocrotonate tautomerase family enzyme.
 
   
 0.911
ADU46698.1
Carbamoyl-phosphate synthase L chain ATP-binding protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR005481: IPR005479: IPR005482: IPR000089: IPR 000022: IPR011761: IPR011764: IPR011763; KEGG: kfl:Kfla_3307 carbamoyl-phosphate synthase L chain ATP-binding protein; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; carboxyl transferase; SPTR: Carbamoyl-phosphate synthase L chain ATP-binding protein; PFAM: Car [...]
  
 
 0.860
ADU49650.1
Acyl-CoA dehydrogenase type 2 domain; COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR013107; KEGG: mab:MAB_0075 putative hydroxylase; PFAM: Acyl-CoA dehydrogenase type 2 domain; SPTR: Putative hydroxylase; PFAM: Acyl-CoA dehydrogenase, C-terminal domain.
 
  0.775
ADU47624.1
Catechol 2,3-dioxygenase; InterPro IPR004360: IPR000486; KEGG: tcu:Tcur_0529 catechol 2,3 dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Catechol 2,3 dioxygenase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: catechol 2,3 dioxygenase.
 
   
 0.772
ADU49652.1
Acyl-CoA dehydrogenase type 2 domain; COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR013107; KEGG: mpa:MAP1448c hypothetical protein; PFAM: Acyl-CoA dehydrogenase type 2 domain; SPTR: Pigment production hydroxylase; PFAM: Acyl-CoA dehydrogenase, C-terminal domain.
 
  0.771
ADU49649.1
Glyoxalase/bleomycin resistance protein/dioxygenase; InterPro IPR003006: IPR004360; KEGG: bav:BAV0594 2,3-dihydroxybiphenyl 1,2-dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Extradiol dioxygenase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: 2,3-dihydroxybiphenyl 1,2-dioxygenase.
 
   
 0.770
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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