| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADU46915.1 | ADU47644.1 | Intca_0366 | Intca_1123 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | 0.817 |
| ADU46915.1 | ADU47739.1 | Intca_0366 | Intca_1221 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.912 |
| ADU46915.1 | ADU47746.1 | Intca_0366 | Intca_1228 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | Biotin carboxyl carrier protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR005481: IPR005479: IPR005482: IPR000089: IPR 001882: IPR011761: IPR011764; KEGG: kse:Ksed_08190 acetyl/propionyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: Putative acyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-te [...] | 0.915 |
| ADU46915.1 | ADU48271.1 | Intca_0366 | Intca_1759 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | Methylmalonate-semialdehyde dehydrogenase (acylating); COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR015590: IPR010061; KEGG: msv:Mesil_1872 methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Methylmalonate-semialdehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. | 0.912 |
| ADU46915.1 | ADU48656.1 | Intca_0366 | Intca_2146 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR012394: IPR016160; KEGG: nda:Ndas_1930 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.912 |
| ADU46915.1 | ADU48771.1 | Intca_0366 | Intca_2262 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845: IPR000873; KEGG: sro:Sros_1890 propionate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetyl-CoA synthetase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | 0.926 |
| ADU46915.1 | ADU49369.1 | Intca_0366 | Intca_2870 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814: IPR004632; KEGG: nml:Namu_4960 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; SPTR: 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.827 |
| ADU46915.1 | acsA | Intca_0366 | Intca_0516 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.918 |
| ADU47643.1 | ADU47644.1 | Intca_1122 | Intca_1123 | Type III effector Hrp-dependent outer domain protein; COGs: COG3395 conserved hypothetical protein; InterPro IPR010737; KEGG: cdi:DIP2080 hypothetical protein; PFAM: type III effector Hrp-dependent outers; SPTR: YgbK domain protein; PFAM: Protein of unknown function, DUF1537. | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | 0.993 |
| ADU47643.1 | ADU47645.1 | Intca_1122 | Intca_1124 | Type III effector Hrp-dependent outer domain protein; COGs: COG3395 conserved hypothetical protein; InterPro IPR010737; KEGG: cdi:DIP2080 hypothetical protein; PFAM: type III effector Hrp-dependent outers; SPTR: YgbK domain protein; PFAM: Protein of unknown function, DUF1537. | COGs: COG2610 H+/gluconate symporter and related permease; InterPro IPR003474; KEGG: spe:Spro_1488 inner membrane permease YgbN; PFAM: Gluconate transporter; SPTR: Gluconate transporter; TIGRFAM: gluconate transporter; PFAM: GntP family permease; TIGRFAM: gluconate transporter. | 0.736 |
| ADU47644.1 | ADU46915.1 | Intca_1123 | Intca_0366 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | 0.817 |
| ADU47644.1 | ADU47643.1 | Intca_1123 | Intca_1122 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | Type III effector Hrp-dependent outer domain protein; COGs: COG3395 conserved hypothetical protein; InterPro IPR010737; KEGG: cdi:DIP2080 hypothetical protein; PFAM: type III effector Hrp-dependent outers; SPTR: YgbK domain protein; PFAM: Protein of unknown function, DUF1537. | 0.993 |
| ADU47644.1 | ADU47645.1 | Intca_1123 | Intca_1124 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG2610 H+/gluconate symporter and related permease; InterPro IPR003474; KEGG: spe:Spro_1488 inner membrane permease YgbN; PFAM: Gluconate transporter; SPTR: Gluconate transporter; TIGRFAM: gluconate transporter; PFAM: GntP family permease; TIGRFAM: gluconate transporter. | 0.839 |
| ADU47644.1 | ADU47739.1 | Intca_1123 | Intca_1221 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.916 |
| ADU47644.1 | ADU47746.1 | Intca_1123 | Intca_1228 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | Biotin carboxyl carrier protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR005481: IPR005479: IPR005482: IPR000089: IPR 001882: IPR011761: IPR011764; KEGG: kse:Ksed_08190 acetyl/propionyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: Putative acyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-te [...] | 0.840 |
| ADU47644.1 | ADU48271.1 | Intca_1123 | Intca_1759 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | Methylmalonate-semialdehyde dehydrogenase (acylating); COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR015590: IPR010061; KEGG: msv:Mesil_1872 methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Methylmalonate-semialdehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. | 0.917 |
| ADU47644.1 | ADU48656.1 | Intca_1123 | Intca_2146 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR012394: IPR016160; KEGG: nda:Ndas_1930 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.916 |
| ADU47644.1 | ADU48771.1 | Intca_1123 | Intca_2262 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845: IPR000873; KEGG: sro:Sros_1890 propionate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetyl-CoA synthetase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | 0.817 |
| ADU47644.1 | ADU49369.1 | Intca_1123 | Intca_2870 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814: IPR004632; KEGG: nml:Namu_4960 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; SPTR: 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.900 |
| ADU47644.1 | acsA | Intca_1123 | Intca_0516 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.817 |