STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psuGIndigoidine synthase A family protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (309 aa)    
Predicted Functional Partners:
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
    
  0.908
ADU47734.1
COGs: COG0213 Thymidine phosphorylase; InterProIPR017459: IPR000312: IPR013102: IPR017872: IPR 018090: IPR000053; KEGG: bcv:Bcav_2940 pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase family 3; Glycosyl transferase, family 3-like; Pyrimidine nucleoside phosphorylase domain; PRIAM: Thymidine phosphorylase; SPTR: Thymidine phosphorylase; TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: pyrimidine-nucleoside phosphorylase.
    
 0.907
pyrR
Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
     
 0.902
ADU47684.1
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611; KEGG: sen:SACE_1230 sugar kinase, phosphofructokinase; PFAM: PfkB domain protein; SPTR: Sugar kinase, possible phosphofructokinase; PFAM: pfkB family carbohydrate kinase.
 
  
 0.901
ADU47682.1
Transcriptional regulator, LysR family; COGs: COG0583 Transcriptional regulator; InterPro IPR000847: IPR005119; KEGG: ade:Adeh_2212 LysR family transcriptional regulator; PFAM: LysR substrate-binding; regulatory protein LysR; SPTR: Transcriptional regulator, LysR family; PFAM: Bacterial regulatory helix-turn-helix protein, lysR family; LysR substrate binding domain.
       0.542
ADU47729.1
Nucleoside-binding protein; COGs: COG1744 Uncharacterized ABC-type transport system periplasmic component/surface lipoprotein; InterPro IPR003760; KEGG: sro:Sros_1269 ABC-type transport system substrate-binding protein; PFAM: basic membrane lipoprotein; SPTR: ABC-type transport system substrate-binding protein; PFAM: Basic membrane protein.
 
     0.540
ADU47731.1
Nucleoside ABC transporter membrane protein; COGs: COG4603 ABC-type uncharacterized transport system permease component; InterPro IPR001851; KEGG: nca:Noca_3539 inner-membrane translocator; PFAM: inner-membrane translocator; SPTR: Inner-membrane translocator; PFAM: Branched-chain amino acid transport system / permease component.
 
     0.437
ADU49326.1
COGs: COG1957 Inosine-uridine nucleoside N-ribohydrolase; InterPro IPR001910; KEGG: nca:Noca_0542 inosine/uridine-preferring nucleoside hydrolase; PFAM: Inosine/uridine-preferring nucleoside hydrolase; SPTR: Inosine/uridine-preferring nucleoside hydrolase; PFAM: Inosine-uridine preferring nucleoside hydrolase.
 
    0.420
ADU47536.1
COGs: COG1957 Inosine-uridine nucleoside N-ribohydrolase; InterPro IPR001910: IPR022272; KEGG: kfl:Kfla_4700 inosine/uridine-preferring nucleoside hydrolase; PFAM: Inosine/uridine-preferring nucleoside hydrolase; SPTR: Inosine/uridine-preferring nucleoside hydrolase; PFAM: Inosine-uridine preferring nucleoside hydrolase.
 
    0.418
rbsK
PfkB domain protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
 
  
 0.411
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.