STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU47714.1Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR005135: IPR004808; KEGG: cfl:Cfla_2498 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth). (294 aa)    
Predicted Functional Partners:
ADU49760.1
COGs: COG0708 Exonuclease III; InterPro IPR004808: IPR000097: IPR005135; KEGG: tfu:Tfu_0258 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
 
  
 
0.927
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.908
ADU46564.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.876
ADU47177.1
COGs: COG1194 A/G-specific DNA glycosylase; InterPro IPR003265: IPR003651: IPR004036; KEGG: tcu:Tcur_4471 HhH-GPD family protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; iron-sulfur cluster loop; SPTR: Putative adenine glycosylase; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif; TIGRFAM: A/G-specific adenine glycosylase.
  
 
 0.867
ADU49932.1
COGs: COG0648 Endonuclease IV; InterPro IPR012307: IPR001719: IPR018246; KEGG: nca:Noca_4666 endonuclease IV; PFAM: Xylose isomerase domain-containing protein TIM barrel; SMART: AP endonuclease family 2; SPTR: Endonuclease IV; manually curated; PFAM: Xylose isomerase-like TIM barrel; TIGRFAM: apurinic endonuclease (APN1).
    
 
 0.793
ADU48349.1
Pseudouridine synthase; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterPro IPR002942: IPR018496: IPR006145: IPR000748; KEGG: kra:Krad_3120 pseudouridine synthase; PFAM: pseudouridine synthase; RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; SPTR: Pseudouridine synthase; PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.
  
    0.790
ADU50023.1
ERCC4 domain protein; InterPro IPR006166; KEGG: nca:Noca_3806 ERCC4 domain-containing protein; PFAM: ERCC4 domain protein; SPTR: ERCC4 domain protein; PFAM: Lsr2.
   
 
 0.773
trpS
tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.739
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.695
ADU47479.1
HhH-GPD family protein; InterPro IPR003265: IPR017658; KEGG: sgr:SGR_3531 hypothetical protein; PFAM: HhH-GPD family protein; SPTR: HhH-GPD family protein; TIGRFAM: HhH-GPD family protein; PFAM: HhH-GPD superfamily base excision DNA repair protein; TIGRFAM: uncharacterized HhH-GPD family protein.
  
 0.674
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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