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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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ADU47907.1Two component transcriptional regulator, LytTR family; COGs: COG3279 Response regulator of the LytR/AlgR family; InterPro IPR001789: IPR007492; KEGG: nca:Noca_0357 response regulator receiver; PFAM: response regulator receiver; LytTr DNA-binding region; SMART: response regulator receiver; SPTR: Response regulator receiver; PFAM: Response regulator receiver domain; LytTr DNA-binding domain. (259 aa)    
Predicted Functional Partners:
ADU47906.1
Signal transduction histidine kinase, LytS; COGs: COG3275 Putative regulator of cell autolysis; InterPro IPR010559: IPR003594; KEGG: nca:Noca_0358 histidine kinase internal region; PFAM: histidine kinase internal region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Histidine kinase internal region; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.974
ADU47908.1
KEGG: tbi:Tbis_2132 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.956
ADU47909.1
COGs: COG4147 symporter; InterPro IPR001734; KEGG: sro:Sros_6322 SSS sodium solute transporter superfamily; PFAM: Na+/solute symporter; SPTR: SSS sodium solute transporter superfamily; PFAM: Sodium:solute symporter family; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
 
     0.944
ADU47911.1
SSS sodium solute transporter superfamily; COGs: COG4147 symporter; InterPro IPR019900: IPR001734; KEGG: bcv:Bcav_3373 SSS sodium solute transporter superfamily; PFAM: Na+/solute symporter; SPTR: SSS sodium solute transporter superfamily; TIGRFAM: SSS sodium solute transporter superfamily; PFAM: Sodium:solute symporter family; TIGRFAM: transporter, SSS family; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
 
     0.648
ADU47910.1
Protein of unknown function DUF485; COGs: COG3162 membrane protein; InterPro IPR007436; KEGG: ske:Sked_13330 predicted membrane protein; PFAM: protein of unknown function DUF485; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function, DUF485.
       0.579
ADU46986.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR000014: IPR000700: IPR 005561: IPR013656: IPR003661: IPR003594: IPR013767: IPR004358; KEGG: ami:Amir_3954 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; response regulator receiver; PAS fold domain protein; ANTAR domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Multi [...]
 
   
 0.527
ADU49069.1
KEGG: tbi:Tbis_1729 hypothetical protein; SPTR: Putative uncharacterized protein.
   
    0.463
ADU49556.1
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR017896: IPR011895: IPR002880: IPR019752: IPR 019456: IPR011766: IPR017900; KEGG: mmi:MMAR_3408 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; TIGRFAM [...]
  
    0.415
obg
GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
       0.412
proA
Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
    
   0.411
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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