STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
thiGThiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (274 aa)    
Predicted Functional Partners:
ADU47919.1
Glycine oxidase ThiO; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR012727: IPR006076; KEGG: sro:Sros_2783 glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; SPTR: Glycine oxidase ThiO; TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; TIGRFAM: glycine oxidase ThiO.
 
 0.999
ADU47918.1
Thiamine biosynthesis protein ThiS; InterPro IPR010035: IPR003749; KEGG: mmi:MMAR_0719 thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
 
 
 0.997
ADU47915.1
COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399: IPR013749; KEGG: nca:Noca_3401 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; PRIAM: Phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
 
  
 0.989
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.988
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.982
ADU47916.1
COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: nca:Noca_3402 thiamine monophosphate synthase; PFAM: thiamine monophosphate synthase; SPTR: Thiamine monophosphate synthase; PFAM: Thiamine monophosphate synthase/TENI; TIGRFAM: thiamine-phosphate pyrophosphorylase.
 
  
 0.972
ADU49066.1
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR001763: IPR000594: IPR007901; KEGG: ace:Acel_1777 molybdopterin biosynthesis-like protein MoeZ; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: UBA/THIF-type NAD/FAD binding protein; PFAM: MoeZ/MoeB domain; Rhodanese-like domain; ThiF family.
 
  
 0.969
dxs
1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.963
ADU48874.1
thiamineS protein; InterPro IPR003749; KEGG: aau:AAur_4051 ThiS family protein; PFAM: thiamineS protein; SPTR: ThiS family protein; PFAM: ThiS family.
   
 
 0.942
ADU49668.1
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR000759: IPR006076; KEGG: sco:SCO6289 secreted oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: Secreted oxidoreductase; PFAM: FAD dependent oxidoreductase.
  
 0.856
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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