Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ADU47946.1Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: gob:Gobs_0866 silent information regulator protein Sir2; PFAM: Silent information regulator protein Sir2; SPTR: Putative SIR2-like regulatory protein; PFAM: Sir2 family. (302 aa)    
Predicted Functional Partners:
ADU47967.1
KEGG: sma:SAV_7225 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function N-terminus (DUF3323); Protein of unknown function C-terminus (DUF2399); TIGRFAM: conserved hypothetical protein TIGR02679.
   
   0.876
ADU49059.1
ATP-dependent DNA helicase, Rep family; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121: IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1179 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: Putative ATP-dependent DNA helicase; manually curated; PFAM: HRDC domain; UvrD/REP helicase.
  
 
 0.864
ADU47191.1
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: kra:Krad_0611 histone deacetylase superfamily; PFAM: histone deacetylase superfamily; PRIAM: Histone deacetylase; SPTR: Putative acetoin utilization protein; PFAM: Histone deacetylase domain.
    
 0.848
ADU49153.1
Transcriptional regulator, HxlR family; COGs: COG1733 transcriptional regulator protein; InterPro IPR002577; KEGG: nfa:nfa24980 putative transcriptional regulator; PFAM: helix-turn-helix HxlR type; SPTR: Putative transcriptional regulator; PFAM: HxlR-like helix-turn-helix.
  
    0.799
ADU49307.1
Transcriptional regulator, MarR family; COGs: COG1846 Transcriptional regulators; InterPro IPR000835; KEGG: rop:ROP_12400 putative MarR family transcriptional regulator; PFAM: regulatory protein MarR; SMART: regulatory protein MarR; SPTR: Putative transcriptional regulator; PFAM: MarR family.
   
    0.763
ADU46801.1
KEGG: mav:MAV_2846 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: TfoX N-terminal domain.
    
   0.761
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.726
ADU47249.1
Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
  
 0.720
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
   0.718
ADU49764.1
COGs: COG3629 DNA-binding transcriptional activator of the SARP family; InterProIPR019775: IPR019782: IPR017986: IPR001680: IPR 001867: IPR005158; KEGG: nml:Namu_2911 transcriptional regulator, SARP family; PFAM: transcriptional activator domain; transcriptional regulator domain-containing protein; SPTR: Transcriptional regulator, SARP family; PFAM: Bacterial transcriptional activator domain; Transcriptional regulatory protein, C terminal.
  
 0.698
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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