STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48076.1KEGG: sen:SACE_5253 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated. (379 aa)    
Predicted Functional Partners:
ADU48077.1
HAD-superfamily hydrolase, subfamily IIA; COGs: COG0647 sugar phosphatase of the HAD superfamily; InterPro IPR005834: IPR006357; KEGG: sro:Sros_6062 sugar phosphatase of the HAD superfamily-like protein; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Sugar phosphatase of the HAD superfamily-like protein; TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase Superfamily Class (subfamily) IIA.
  
 
 0.984
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
 0.920
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.884
ADU47546.1
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG2303 Choline dehydrogenase and related flavoprotein; InterPro IPR013027; KEGG: rer:RER_19350 hypothetical protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Putative cholesterol oxidase; PFAM: GMC oxidoreductase.
    
 0.838
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
   
 0.836
ADU49308.1
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR000595: IPR003594: IPR005467: IPR004358; KEGG: rha:RHA1_ro04003 sensor kinase, two-component system; PFAM: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SMART: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SPTR: Histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
   
 0.836
ADU48807.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002332: IPR002187; KEGG: ace:Acel_1565 nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Putative nitrogen regulatory protein P-II; PFAM: Nitrogen regulatory protein P-II.
    
 
 0.820
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
 
  0.819
ADU48081.1
DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA.
     
 0.796
ADU49998.1
Chalcone and stilbene synthase domain protein; COGs: COG3424 naringenin-chalcone synthase; InterPro IPR011141: IPR001099: IPR012328; KEGG: kse:Ksed_00500 predicted naringenin-chalcone synthase; PFAM: chalcone and stilbene synthase domain protein; SPTR: Chalcone and stilbene synthases domain-containing protein; PFAM: FAE1/Type III polyketide synthase-like protein; Chalcone and stilbene synthases, C-terminal domain.
    
 0.779
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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