STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ADU48135.1COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: sgr:SGR_6090 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Putative riboflavin synthase alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (203 aa)    
Predicted Functional Partners:
ADU48134.1
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
 0.999
ribA-2
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family.
 
 0.999
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.999
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
 
 0.981
ADU48731.1
Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR004821: IPR002606: IPR015864: IPR015865; KEGG: ske:Sked_23420 FMN adenylyltransferase/riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin kinase/ FMN adenyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; manually curated; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family.
  
 
 0.927
ADU49380.1
Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase.
     
  0.900
ADU47554.1
Bifunctional deaminase-reductase domain protein; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR002734; KEGG: nca:Noca_1683 deaminase-reductase domain-containing protein; PFAM: bifunctional deaminase-reductase domain protein; SPTR: Bifunctional deaminase-reductase domain protein; PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain.
 
  
 0.893
ADU48133.1
COGs: COG3201 Nicotinamide mononucleotide transporter; InterPro IPR006419; KEGG: cef:CE0081 hypothetical protein; PFAM: Nicotinamide mononucleotide transporter PnuC; SPTR: Mononucleotide transporter; TIGRFAM: nicotinamide mononucleotide transporter PnuC; PFAM: Nicotinamide mononucleotide transporter; TIGRFAM: nicotinamide mononucleotide transporter PnuC.
       0.837
ADU48414.1
Bifunctional deaminase-reductase domain protein; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR002734; KEGG: nca:Noca_4154 hypothetical protein; PFAM: bifunctional deaminase-reductase domain protein; SPTR: Bifunctional deaminase-reductase domain protein; PFAM: RibD C-terminal domain.
 
  
 0.799
hisE
COGs: COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; InterPro IPR008179: IPR021130; KEGG: nda:Ndas_5379 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase.
  
    0.735
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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