STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADU48141.1COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tcu:Tcur_3523 flavin reductase domain protein FMN-binding protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Nitrilotriacetate monooxygenase component B; PFAM: Flavin reductase like domain. (182 aa)    
Predicted Functional Partners:
ADU49652.1
Acyl-CoA dehydrogenase type 2 domain; COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR013107; KEGG: mpa:MAP1448c hypothetical protein; PFAM: Acyl-CoA dehydrogenase type 2 domain; SPTR: Pigment production hydroxylase; PFAM: Acyl-CoA dehydrogenase, C-terminal domain.
 
 
 0.959
ADU49650.1
Acyl-CoA dehydrogenase type 2 domain; COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR013107; KEGG: mab:MAB_0075 putative hydroxylase; PFAM: Acyl-CoA dehydrogenase type 2 domain; SPTR: Putative hydroxylase; PFAM: Acyl-CoA dehydrogenase, C-terminal domain.
 
 
 0.958
ADU48140.1
KEGG: cfl:Cfla_1864 protein of unknown function DUF2581; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2581).
  
  
 0.788
hisG
ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
       0.778
ribA-2
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family.
  
  
 0.706
hisE
COGs: COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; InterPro IPR008179: IPR021130; KEGG: nda:Ndas_5379 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase.
       0.602
ADU48134.1
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.482
ADU49803.1
Luciferase family oxidoreductase, group 1; COGs: COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase; InterPro IPR019949: IPR016048; KEGG: cwo:Cwoe_3321 luciferase family oxidoreductase, group 1; PFAM: Luciferase-like, subgroup; SPTR: Luciferase family oxidoreductase, group 1; TIGRFAM: luciferase family oxidoreductase, group 1; PFAM: Luciferase-like monooxygenase; TIGRFAM: luciferase family oxidoreductase, group 1.
  
  
 0.474
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
  
 0.432
ADU49649.1
Glyoxalase/bleomycin resistance protein/dioxygenase; InterPro IPR003006: IPR004360; KEGG: bav:BAV0594 2,3-dihydroxybiphenyl 1,2-dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Extradiol dioxygenase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: 2,3-dihydroxybiphenyl 1,2-dioxygenase.
 
     0.426
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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