STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
moaAGTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (350 aa)    
Predicted Functional Partners:
ADU47419.1
GTP cyclohydrolase subunit MoaC; COGs: COG0315 Molybdenum cofactor biosynthesis enzyme; InterPro IPR002820; KEGG: gob:Gobs_4471 molybdenum cofactor biosynthesis protein C; PFAM: molybdopterin cofactor biosynthesis protein MoaC; SPTR: Molybdenum cofactor biosynthesis protein C; TIGRFAM: molybdenum cofactor biosynthesis protein C; PFAM: MoaC family; TIGRFAM: molybdenum cofactor biosynthesis protein MoaC.
 
 0.999
ADU49048.1
COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR003448; KEGG: scb:SCAB_30561 putative MoaE-like protein; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: Molybdopterin biosynthesis protein E; PFAM: MoaE protein.
 
  
 0.959
ADU47420.1
COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR001453: IPR020817: IPR008284; KEGG: kfl:Kfla_5764 molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; SPTR: Putative molybdopterin biosynthesis protein; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain.
 
  
 0.933
ADU46684.1
Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
 
 0.926
folE
COGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602: IPR001474: IPR018234; KEGG: ske:Sked_32080 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
    
  0.908
ribA-2
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family.
    
 0.905
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
     
  0.900
ADU49373.1
Molybdenum ABC transporter, periplasmic molybdate-binding protein; COGs: COG0725 ABC-type molybdate transport system periplasmic component; InterPro IPR006059: IPR005950: IPR010916; KEGG: kfl:Kfla_6495 molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: extracellular solute-binding protein family 1; SPTR: Molybdenum ABC transporter, periplasmic molybdate-binding protein; TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: Bacterial extracellular solute-binding protein; TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding [...]
 
  
 0.867
ADU47418.1
Molybdenum cofactor synthesis domain protein; COGs: COG0303 Molybdopterin biosynthesis enzyme; InterProIPR002618: IPR005110: IPR001453: IPR005111: IPR 020817; KEGG: kfl:Kfla_5768 UTP--glucose-1-phosphate uridylyltransferase; PFAM: UTP--glucose-1-phosphate uridylyltransferase; MoeA domain protein domain I and II; molybdopterin binding domain; MoeA domain protein domain IV; PRIAM: UTP--glucose-1-phosphate uridylyltransferase; SPTR: UTP--glucose-1-phosphate uridylyltransferase; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; MoeA N-termi [...]
 
 0.856
ADU47764.1
COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: art:Arth_1285 putative adenylate/guanylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; PRIAM: Adenylate cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylyl cyclase class-3/4/guanylyl cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain.
   
  0.813
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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