STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ADU48236.1Enoyl-(acyl-carrier-protein) reductase (NADH); COGs: COG0623 Enoyl-(acyl-carrier-protein); InterPro IPR002198; KEGG: cfl:Cfla_1687 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Enoyl-(Acyl carrier protein) reductase; PFAM: short chain dehydrogenase. (253 aa)    
Predicted Functional Partners:
ADU49522.1
COGs: COG0777 Acetyl-CoA carboxylase beta subunit; InterPro IPR011762: IPR011763: IPR000438: IPR000022; KEGG: nca:Noca_4502 carboxyl transferase; PFAM: carboxyl transferase; SPTR: Carboxyl transferase; PFAM: Carboxyl transferase domain; TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit.
  
  
 0.981
ADU48576.1
3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
  
 0.960
ADU48573.1
COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043; KEGG: ach:Achl_2205 putative (acyl-carrier-protein) S-malonyltransferase; PFAM: Acyl transferase; PRIAM: [Acyl-carrier-protein] S-malonyltransferase; SPTR: Acyl-carrier-protein S-malonyltransferase; PFAM: Acyl transferase domain.
 
  
 0.951
fabH
3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
  
 0.929
acpP
Phosphopantetheine-binding protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 
 0.924
ADU48235.1
3-oxoacyl-(acyl-carrier-protein) reductase; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR002198: IPR011284; KEGG: mlu:Mlut_11580 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: 3-oxoacyl-[acyl-carrier protein] reductase; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: short chain dehydrogenase; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase.
 
  
 0.769
ADU46698.1
Carbamoyl-phosphate synthase L chain ATP-binding protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR005481: IPR005479: IPR005482: IPR000089: IPR 000022: IPR011761: IPR011764: IPR011763; KEGG: kfl:Kfla_3307 carbamoyl-phosphate synthase L chain ATP-binding protein; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; carboxyl transferase; SPTR: Carbamoyl-phosphate synthase L chain ATP-binding protein; PFAM: Car [...]
  
  
 0.750
ADU47837.1
Isochorismatase hydrolase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: ami:Amir_1003 isochorismatase hydrolase; PFAM: isochorismatase hydrolase; SPTR: Isochorismatase hydrolase; PFAM: Isochorismatase family.
     
 0.678
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.668
rpsL
SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
      
 0.668
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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