Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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ADU48274.1Peptidase M50; COGs: COG1994 Zn-dependent protease; InterPro IPR000644: IPR008915; KEGG: xce:Xcel_1483 peptidase M50; PFAM: peptidase M50; SPTR: Putative peptidase; PFAM: Peptidase family M50. (386 aa)    
Predicted Functional Partners:
ADU49744.1
COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR002173: IPR017583: IPR011611; KEGG: sen:SACE_2273 putative 6-phosphofructokinase; PFAM: PfkB domain protein; PRIAM: 1-phosphofructokinase; SPTR: Putative 6-phosphofructokinase; TIGRFAM: 1-phosphofructokinase; PFAM: pfkB family carbohydrate kinase; TIGRFAM: 1-phosphofructokinase; hexose kinase, 1-phosphofructokinase family.
  
    0.801
ADU46937.1
Major facilitator superfamily MFS_1; COGs: COG2223 Nitrate/nitrite transporter; InterPro IPR011701: IPR001412; KEGG: stp:Strop_0176 major facilitator transporter; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily.
  
    0.679
ADU48273.1
COGs: COG2887 RecB family exonuclease; KEGG: kfl:Kfla_3207 RecB family exonuclease-like protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2800).
 
    0.649
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
     0.591
ADU49901.1
Putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase; COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000595: IPR000644: IPR005105: IPR018821; KEGG: tra:Trad_0246 putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase; PFAM: protein of unknown function DUF294 nucleotidyltransferase; CBS domain containing protein; cyclic nucleotide-binding; Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding; SMART: CBS domain containing protein; cyclic nucleotide-binding; SPTR: Puta [...]
  
    0.584
ADU49906.1
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644; KEGG: sen:SACE_3488 CBS domain-containing protein; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: CBS domain protein; PFAM: CBS domain.
  
    0.584
ADU48276.1
COGs: COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferase; InterPro IPR014816; KEGG: cfl:Cfla_2005 tRNA (adenine-N(1)-)-methyltransferase; PFAM: tRNA methyltransferase complex GCD14 subunit; PRIAM: tRNA (adenine-N(1)-)-methyltransferase; SPTR: Putative uncharacterized protein; PFAM: tRNA methyltransferase complex GCD14 subunit.
       0.583
ADU49846.1
C4-dicarboxylate transporter/malic acid transport protein; COGs: COG1275 Tellurite resistance protein and related permease; InterPro IPR004695; KEGG: nca:Noca_3979 C4-dicarboxylate transporter/malic acid transport protein; PFAM: C4-dicarboxylate transporter/malic acid transport protein; SPTR: C4-dicarboxylate transporter/malic acid transport protein; PFAM: C4-dicarboxylate transporter/malic acid transport protein.
   
  
 0.574
ADU48275.1
InterPro IPR000424; KEGG: nca:Noca_2477 single-strand binding protein/primosomal replication protein N; PFAM: single-strand binding protein/Primosomal replication protein n; SPTR: Putative uncharacterized protein; PFAM: Single-strand binding protein family.
 
     0.544
ADU48258.1
KEGG: bfa:Bfae_16260 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.539
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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