STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48276.1COGs: COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferase; InterPro IPR014816; KEGG: cfl:Cfla_2005 tRNA (adenine-N(1)-)-methyltransferase; PFAM: tRNA methyltransferase complex GCD14 subunit; PRIAM: tRNA (adenine-N(1)-)-methyltransferase; SPTR: Putative uncharacterized protein; PFAM: tRNA methyltransferase complex GCD14 subunit. (369 aa)    
Predicted Functional Partners:
ADU48269.1
HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG0637 phosphatase/phosphohexomutase; InterPro IPR005834: IPR006402; KEGG: bcv:Bcav_2245 HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED.
     0.911
ADU48275.1
InterPro IPR000424; KEGG: nca:Noca_2477 single-strand binding protein/primosomal replication protein N; PFAM: single-strand binding protein/Primosomal replication protein n; SPTR: Putative uncharacterized protein; PFAM: Single-strand binding protein family.
   
   0.775
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
     0.760
rpmD
COGs: COG1841 Ribosomal protein L30/L7E; InterPro IPR005996: IPR000517; KEGG: sro:Sros_1104 ribosomal protein L30p/L7e; PFAM: ribosomal protein L30; SPTR: 50S ribosomal protein L30; TIGRFAM: ribosomal protein L30; PFAM: Ribosomal protein L30p/L7e; TIGRFAM: ribosomal protein L30, bacterial/organelle.
   
   0.747
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
 
 0.695
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
    0.622
ADU48274.1
Peptidase M50; COGs: COG1994 Zn-dependent protease; InterPro IPR000644: IPR008915; KEGG: xce:Xcel_1483 peptidase M50; PFAM: peptidase M50; SPTR: Putative peptidase; PFAM: Peptidase family M50.
       0.602
ADU48315.1
23S rRNA m(5)U-747 methyltransferase; COGs: COG2265 SAM-dependent methyltransferase related to tRNA (uracil-5-)-methyltransferase; InterPro IPR010280; KEGG: ach:Achl_1142 23S rRNA methyluridine methyltransferase; PFAM: (Uracil-5)-methyltransferase; SPTR: 23S rRNA (Uracil-5-)-methyltransferase RumB; PFAM: tRNA (Uracil-5-)-methyltransferase; TIGRFAM: 23S rRNA (uracil-5-)-methyltransferase RumB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
   
  
 0.576
ADU48439.1
23S rRNA m(5)U-1939 methyltransferase; COGs: COG2265 SAM-dependent methyltransferase related to tRNA (uracil-5-)-methyltransferase; InterPro IPR002792; KEGG: kra:Krad_1564 deoxyribonuclease/rho motif-related TRAM; PFAM: deoxyribonuclease/rho motif-related TRAM; SPTR: Putative RNA methyltransferase; PFAM: tRNA (Uracil-5-)-methyltransferase; TRAM domain; TIGRFAM: 23S rRNA (uracil-5-)-methyltransferase RumA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
   
  
 0.576
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.565
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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