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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48340.1Isochorismatase hydrolase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR003881: IPR000868; KEGG: sro:Sros_6622 isochorismatase hydrolase; PFAM: isochorismatase hydrolase; SPTR: Isochorismatase hydrolase; PFAM: Isochorismatase family. (206 aa)    
Predicted Functional Partners:
ADU48341.1
5-oxoprolinase (ATP-hydrolyzing); COGs: COG0146 N-methylhydantoinase B/acetone carboxylase alpha subunit; InterPro IPR003692; KEGG: gbr:Gbro_2859 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase B/oxoprolinase; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase B/oxoprolinase.
 
     0.933
ADU48342.1
5-oxoprolinase (ATP-hydrolyzing); COGs: COG0145 N-methylhydantoinase A/acetone carboxylase beta subunit; InterPro IPR008040: IPR002821; KEGG: gbr:Gbro_2860 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; PRIAM: 5-oxoprolinase (ATP-hydrolyzing); SPTR: 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinase/oxoprolinase N-terminal region.
 
     0.895
ADU48339.1
hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: fre:Franean1_3719 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: Pyruvate carboxyltransferase; PFAM: HMGL-like.
  
    0.785
ADU48343.1
succinyl-CoA:(R)-citramalate CoA-transferase; COGs: COG1804 acyl-CoA transferase/carnitine dehydratase; InterPro IPR003673; KEGG: sro:Sros_6621 formyl-CoA transferase; PFAM: L-carnitine dehydratase/bile acid-inducible protein F; PRIAM: Formyl-CoA transferase; SPTR: Formyl-CoA transferase; PFAM: CoA-transferase family III; Belongs to the CoA-transferase III family.
  
    0.780
ADU48338.1
Major facilitator superfamily MFS_1; COGs: COG2814 Arabinose efflux permease; InterPro IPR011701; KEGG: rxy:Rxyl_2414 major facilitator transporter; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily.
 
     0.709
ADU47228.1
COGs: COG1169 Isochorismate synthase; InterPro IPR015890: IPR004561; KEGG: kfl:Kfla_6301 isochorismate synthase; PFAM: Chorismate binding-like; SPTR: Isochorismate synthase; TIGRFAM: isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases.
    
 0.638
ADU48344.1
Transcriptional regulator, GntR family; COGs: COG1802 Transcriptional regulators; InterPro IPR000524: IPR011711; KEGG: pzu:PHZ_c2130 transcriptional regulator, GntR family; PFAM: GntR domain protein; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH; SPTR: Transcriptional regulator, GntR family; PFAM: Bacterial regulatory proteins, gntR family; FCD domain.
       0.551
nnrE
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
   
    0.478
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.444
ADU47961.1
COGs: COG2421 acetamidase/formamidase; InterPro IPR004304; KEGG: gob:Gobs_1964 acetamidase/formamidase; PFAM: Acetamidase/Formamidase; SPTR: Acetamidase/Formamidase; PFAM: Acetamidase/Formamidase family.
 
    0.417
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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