STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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ADU48414.1Bifunctional deaminase-reductase domain protein; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR002734; KEGG: nca:Noca_4154 hypothetical protein; PFAM: bifunctional deaminase-reductase domain protein; SPTR: Bifunctional deaminase-reductase domain protein; PFAM: RibD C-terminal domain. (254 aa)    
Predicted Functional Partners:
ribA-2
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family.
 
 
 0.903
ADU48135.1
COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: sgr:SGR_6090 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Putative riboflavin synthase alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit.
 
  
 0.828
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.709
ADU48413.1
Protein of unknown function DUF344; COGs: COG2326 conserved hypothetical protein; InterPro IPR005660: IPR016898; KEGG: kse:Ksed_15560 hypothetical protein; PFAM: protein of unknown function DUF344; SPTR: Uncharacterized conserved protein; PFAM: Polyphosphate kinase 2 (PPK2); TIGRFAM: polyphosphate:nucleotide phosphotransferase, PPK2 family.
       0.610
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
   0.595
ADU47148.1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.514
ADU46860.1
COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489: IPR006390; KEGG: pfr:PFREUD_02120 dihydropteroate synthase ((2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl- diphosphate:4-am inobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase); PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Dihydropteroate synthase ((2-amino-4-hydroxy-7, 8-dihydropteridin-6-yl)methyl-diphosphate:4- aminobenzoate 2-amino-4-hydroxydihydropteridine-6- methenyltransferase); TIGRFAM: dihydropteroate synthase; manually curated; PFAM: Pterin binding enzyme; TIGRFAM: [...]
 
   
 0.460
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
  
 
 0.432
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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