STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48466.1COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013: IPR011708: IPR004365: IPR003141: IPR 004805; KEGG: kra:Krad_3215 DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: Putative DNA polymerase III alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (pol [...] (1391 aa)    
Predicted Functional Partners:
ADU48667.1
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR005790: IPR010372; KEGG: bcv:Bcav_1739 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: Putative DNA-binding protein; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
  
 
 0.872
ADU46564.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 
 0.867
ADU48468.1
KEGG: kra:Krad_3217 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.859
dinB
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
  
 0.855
ADU48467.1
KEGG: kse:Ksed_16050 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.820
ADU49902.1
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR013520: IPR006055; KEGG: mgm:Mmc1_1044 exonuclease, RNase T and DNA polymerase III; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; SPTR: Exonuclease RNase T and DNA polymerase III; PFAM: Exonuclease.
   
 
 0.788
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 
 0.784
ADU47116.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR003593; KEGG: kse:Ksed_24860 DNA polymerase III, gamma/tau subunit; SMART: AAA ATPase; SPTR: ATPase; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: DNA polymerase III, delta' subunit.
  
 
 0.784
ADU48437.1
KEGG: kse:Ksed_15730 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.762
ADU48465.1
Methyltransferase type 12; COGs: COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase; InterPro IPR013217; KEGG: tcu:Tcur_2941 methyltransferase type 11; PFAM: Methyltransferase type 12; SPTR: Putative methyltransferase; PFAM: Methyltransferase domain.
 
   
 0.744
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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