| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADU47001.1 | ADU48512.1 | Intca_0453 | Intca_2001 | ABC transporter related protein; COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003439: IPR017940: IPR003593; KEGG: nca:Noca_2806 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter related; PFAM: ABC transporter transmembrane region; ABC transporter. | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | 0.428 |
| ADU47843.1 | ADU48512.1 | Intca_1327 | Intca_2001 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | 0.789 |
| ADU47843.1 | ADU49201.1 | Intca_1327 | Intca_2699 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.501 |
| ADU48510.1 | ADU48512.1 | Intca_1999 | Intca_2001 | COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: tfu:Tfu_1010 glycerate kinase; PFAM: glycerate kinase; PRIAM: Glycerate kinase; SPTR: Glycerate kinase; TIGRFAM: glycerate kinase; PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | 0.426 |
| ADU48510.1 | nadA | Intca_1999 | Intca_2000 | COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: tfu:Tfu_1010 glycerate kinase; PFAM: glycerate kinase; PRIAM: Glycerate kinase; SPTR: Glycerate kinase; TIGRFAM: glycerate kinase; PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.621 |
| ADU48512.1 | ADU47001.1 | Intca_2001 | Intca_0453 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | ABC transporter related protein; COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003439: IPR017940: IPR003593; KEGG: nca:Noca_2806 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter related; PFAM: ABC transporter transmembrane region; ABC transporter. | 0.428 |
| ADU48512.1 | ADU47843.1 | Intca_2001 | Intca_1327 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.789 |
| ADU48512.1 | ADU48510.1 | Intca_2001 | Intca_1999 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: tfu:Tfu_1010 glycerate kinase; PFAM: glycerate kinase; PRIAM: Glycerate kinase; SPTR: Glycerate kinase; TIGRFAM: glycerate kinase; PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. | 0.426 |
| ADU48512.1 | ADU49201.1 | Intca_2001 | Intca_2699 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.410 |
| ADU48512.1 | ADU49270.1 | Intca_2001 | Intca_2769 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | KEGG: kfl:Kfla_6144 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.533 |
| ADU48512.1 | ADU49271.1 | Intca_2001 | Intca_2770 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | KEGG: sma:SAV_5893 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.533 |
| ADU48512.1 | ADU49895.1 | Intca_2001 | Intca_3415 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | Ankyrin; InterPro IPR002110: IPR020683; KEGG: nda:Ndas_2707 ankyrin; PFAM: Ankyrin; SMART: Ankyrin; SPTR: Ankyrin; PFAM: Ankyrin repeat. | 0.533 |
| ADU48512.1 | nadA | Intca_2001 | Intca_2000 | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.654 |
| ADU49201.1 | ADU47843.1 | Intca_2699 | Intca_1327 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.501 |
| ADU49201.1 | ADU48512.1 | Intca_2699 | Intca_2001 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | 0.410 |
| ADU49270.1 | ADU48512.1 | Intca_2769 | Intca_2001 | KEGG: kfl:Kfla_6144 hypothetical protein; SPTR: Putative uncharacterized protein. | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | 0.533 |
| ADU49270.1 | ADU49271.1 | Intca_2769 | Intca_2770 | KEGG: kfl:Kfla_6144 hypothetical protein; SPTR: Putative uncharacterized protein. | KEGG: sma:SAV_5893 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.936 |
| ADU49271.1 | ADU48512.1 | Intca_2770 | Intca_2001 | KEGG: sma:SAV_5893 hypothetical protein; SPTR: Putative uncharacterized protein. | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | 0.533 |
| ADU49271.1 | ADU49270.1 | Intca_2770 | Intca_2769 | KEGG: sma:SAV_5893 hypothetical protein; SPTR: Putative uncharacterized protein. | KEGG: kfl:Kfla_6144 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.936 |
| ADU49895.1 | ADU48512.1 | Intca_3415 | Intca_2001 | Ankyrin; InterPro IPR002110: IPR020683; KEGG: nda:Ndas_2707 ankyrin; PFAM: Ankyrin; SMART: Ankyrin; SPTR: Ankyrin; PFAM: Ankyrin repeat. | Metallophosphoesterase; InterPro IPR011152; KEGG: cfl:Cfla_2021 metallophosphoesterase; SPTR: Metallophosphoesterase. | 0.533 |