STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48544.1M6 family metalloprotease domain protein; COGs: COG4412 conserved hypothetical protein; InterPro IPR008757: IPR012300: IPR017683; KEGG: rxy:Rxyl_1277 peptidase M6, immune inhibitor A; PFAM: peptidase M6 immune inhibitor A; SPTR: Putative secreted protease; TIGRFAM: M6 family metalloprotease domain protein; PFAM: Immune inhibitor A peptidase M6; TIGRFAM: M6 family metalloprotease domain. (765 aa)    
Predicted Functional Partners:
ADU49210.1
InterPro IPR001845; KEGG: xce:Xcel_0321 transcriptional regulator, ArsR family; PFAM: regulatory protein ArsR; SMART: regulatory protein ArsR; SPTR: Putative ArsR-family transcriptional regulator; PFAM: Bacterial regulatory protein, arsR family.
  
     0.586
ADU48543.1
COGs: COG0174 Glutamine synthetase; InterPro IPR008147: IPR008146; KEGG: tbi:Tbis_1258 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Glutamine synthetase type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
       0.515
panB
Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.515
glnE
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
       0.490
ADU49211.1
InterPro IPR011701: IPR005829; KEGG: xce:Xcel_0322 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily.
  
     0.488
ADU49301.1
InterPro IPR000182; KEGG: cmi:CMM_0281 putative acetyltransferase; SPTR: Putative acetyltransferase.
  
     0.485
ADU48541.1
InterPro IPR011701; KEGG: gob:Gobs_1534 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily.
       0.476
ADU47517.1
KEGG: kse:Ksed_07270 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.464
ADU48903.1
Hypothetical protein; InterPro IPR010916; KEGG: kse:Ksed_09580 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.458
ADU48007.1
KEGG: tbi:Tbis_2449 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.447
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.