STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48560.1COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: gob:Gobs_3460 phosphoglycerate mutase; PFAM: ribonuclease H; SPTR: Bifunctional RNase H/acid phosphatase; PFAM: RNase H. (350 aa)    
Predicted Functional Partners:
ADU48561.1
Protein of unknown function DUF164; COGs: COG1579 Zn-ribbon protein possibly nucleic acid-binding; InterPro IPR003743; KEGG: tcu:Tcur_1674 protein of unknown function DUF164; PFAM: protein of unknown function DUF164; SPTR: Zn-ribbon protein-like protein; manually curated; PFAM: Putative zinc ribbon domain.
  
  
 0.908
cobT
Nicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
     
  0.900
cobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
     
  0.900
ADU48562.1
Protein of unknown function DUF34; COGs: COG0327 conserved hypothetical protein; InterPro IPR002678; KEGG: xce:Xcel_2085 protein of unknown function DUF34; PFAM: protein of unknown function DUF34; SPTR: Putative uncharacterized protein; PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: dinuclear metal center protein, YbgI/SA1388 family.
  
  
 0.845
ADU49065.1
Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding protein; COGs: COG3695 methylated DNA-protein cysteine methyltransferase; InterPro IPR014048: IPR004360; KEGG: cfl:Cfla_0254 glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain.
 
      0.839
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.791
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
   
   0.727
ADU48559.1
Rhodanese domain protein; InterPro IPR001763; KEGG: cfl:Cfla_2946 rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: Putative uncharacterized protein; PFAM: Rhodanese-like domain.
  
    0.702
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.611
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.568
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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