STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48579.1HNH endonuclease; COGs: COG1403 Restriction endonuclease; InterPro IPR002711: IPR003615; KEGG: kfl:Kfla_6715 HNH endonuclease; PFAM: HNH endonuclease; SMART: HNH nuclease; SPTR: HNH endonuclease; PFAM: HNH endonuclease. (165 aa)    
Predicted Functional Partners:
ADU48578.1
Transcription factor WhiB; InterPro IPR003482; KEGG: cai:Caci_7795 transcription factor WhiB; PFAM: transcription factor WhiB; SPTR: Transcription factor WhiB; PFAM: Transcription factor WhiB.
 
     0.824
ADU48577.1
Protein of unknown function UPF0027; COGs: COG1690 conserved hypothetical protein; InterPro IPR001233; KEGG: pfr:PFREUD_23600 hypothetical protein; PFAM: protein of unknown function UPF0027; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein family UPF0027.
 
     0.592
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
     
 0.513
ruvC
Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
      
 0.489
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
      
 0.463
ADU48580.1
KEGG: aau:AAur_2439 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3145).
       0.409
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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