Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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ADU48632.1ABC transporter related protein; COGs: COG1121 ABC-type Mn/Zn transport systems ATPase component; InterPro IPR003439: IPR003593: IPR017871; KEGG: gob:Gobs_1601 ABC transporter related protein; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC-type Mn/Zn transport systems ATPase component; PFAM: ABC transporter. (268 aa)    
Predicted Functional Partners:
ADU48633.1
ABC-3 protein; COGs: COG1108 ABC-type Mn2+/Zn2+ transport systems permease components; InterPro IPR001626; KEGG: gob:Gobs_1600 ABC-3 protein; PFAM: ABC-3 protein; SPTR: Putative metal transport ABC transporter; PFAM: ABC 3 transport family.
 
 0.999
ADU48631.1
Periplasmic solute binding protein; COGs: COG0803 ABC-type metal ion transport system periplasmic component/surface adhesin; InterPro IPR006129: IPR006128: IPR006127; KEGG: gob:Gobs_1602 periplasmic solute binding protein; PFAM: periplasmic solute binding protein; SPTR: Putative ABC-transporter metal-binding lipoprotein; PFAM: Periplasmic solute binding protein family; Belongs to the bacterial solute-binding protein 9 family.
 
 
 0.998
ADU48634.1
Zinc uptake regulator, Fur family; COGs: COG0735 Fe2+/Zn2+ uptake regulation protein; InterPro IPR002481; KEGG: mmi:MMAR_3669 zinc uptake regulation protein Zur; PFAM: ferric-uptake regulator; SPTR: Zinc uptake regulation protein Zur; PFAM: Ferric uptake regulator family; Belongs to the Fur family.
  
  
 0.919
ADU48630.1
KEGG: sro:Sros_2344 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.639
dnaJ
Chaperone DnaJ domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...]
  
 
 
 0.606
ADU48629.1
Rhodanese domain protein; COGs: COG2897 Rhodanese-related sulfurtransferase; InterPro IPR001763: IPR001307; KEGG: kfl:Kfla_3476 rhodanese domain protein; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: Rhodanese domain protein; PFAM: Rhodanese-like domain.
       0.586
ADU48627.1
TIM-barrel protein, nifR3 family; COGs: COG0042 tRNA-dihydrouridine synthase; InterPro IPR001269: IPR004652: IPR018517; KEGG: kse:Ksed_11870 putative TIM-barrel protein, nifR3 family; PFAM: dihydrouridine synthase DuS; SPTR: Transcriptional regulator, NifR3/Smm1 family protein; TIGRFAM: TIM-barrel protein, nifR3 family; PFAM: Dihydrouridine synthase (Dus); TIGRFAM: putative TIM-barrel protein, nifR3 family.
       0.556
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
   
 0.539
ADU47307.1
Heavy metal translocating P-type ATPase; COGs: COG2217 Cation transport ATPase; InterProIPR006121: IPR001757: IPR008250: IPR005834: IPR 006403: IPR006416: IPR018303; KEGG: rha:RHA1_ro11210 copper-exporting ATPase; PFAM: E1-E2 ATPase-associated domain protein; Heavy metal transport/detoxification protein; Haloacid dehalogenase domain protein hydrolase; SPTR: Putative cation-transporting ATPase; TIGRFAM: heavy metal translocating P-type ATPase; copper-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; Heavy-metal-associated doma [...]
 
   
 0.515
tsaD
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
  
     0.484
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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