STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48645.1COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR002550: IPR000644: IPR005170; KEGG: kse:Ksed_11750 CBS domain-containing protein; PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; SMART: CBS domain containing protein; SPTR: Putative membrane protein; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain. (437 aa)    
Predicted Functional Partners:
ybeY
Protein of unknown function UPF0054; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  
  
 0.883
ADU48647.1
PhoH family protein; COGs: COG1702 Phosphate starvation-inducible protein PhoH predicted ATPase; InterPro IPR003714: IPR008162; KEGG: kra:Krad_3387 PhoH family protein; PFAM: PhoH family protein; SPTR: PhoH-like protein; PFAM: PhoH-like protein.
  
    0.864
era
GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
  
    0.857
ADU48649.1
Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310; KEGG: nda:Ndas_0706 histidine triad (HIT) protein; PFAM: histidine triad (HIT) protein; SPTR: Histidine triad (HIT) protein; PFAM: HIT domain.
       0.810
ADU48648.1
COGs: COG2939 Carboxypeptidase C (cathepsin A); InterPro IPR001563; KEGG: svi:Svir_32200 carboxypeptidase C (cathepsin A); PFAM: peptidase S10 serine carboxypeptidase; SPTR: Carboxypeptidase C (Cathepsin A); PFAM: Serine carboxypeptidase.
       0.762
ADU48651.1
Lipoprotein LpqB, GerMN domain; InterPro IPR019606: IPR018911; KEGG: kra:Krad_3401 hypothetical protein; PFAM: Lipoprotein LpqB, GerMN domain; Spore germination protein-like Gmad2, bacteria; SPTR: Putative uncharacterized protein; PFAM: Sporulation and spore germination; Immunoglobulin-like domain of bacterial spore germination.
       0.550
ADU48650.1
RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR007627: IPR013249: IPR014325: IPR014284; KEGG: ace:Acel_0787 ECF subfamily RNA polymerase sigma-24 factor; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; SPTR: Putative RNA polymerase ECF-subfamily sigma factor; TIGRFAM: RNA polymerase sigma-70 factor, sigma-E family; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymera [...]
       0.546
ADU48079.1
COGs: COG1189 rRNA methylase; InterPro IPR002942: IPR002877: IPR004538; KEGG: mlu:Mlut_14230 hemolysin A; PFAM: RNA-binding S4 domain protein; ribosomal RNA methyltransferase RrmJ/FtsJ; SMART: RNA-binding S4 domain protein; SPTR: Hemolysin A; TIGRFAM: hemolysin A; PFAM: S4 domain; FtsJ-like methyltransferase; TIGRFAM: hemolysin TlyA family protein.
     
 0.479
ADU50123.1
Protein of unknown function DUF37; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.
     
 0.476
dnaJ
Chaperone DnaJ domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...]
 
     0.447
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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