| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADU46915.1 | ADU47644.1 | Intca_0366 | Intca_1123 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | 0.811 |
| ADU46915.1 | ADU47739.1 | Intca_0366 | Intca_1221 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.929 |
| ADU46915.1 | ADU48271.1 | Intca_0366 | Intca_1759 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | Methylmalonate-semialdehyde dehydrogenase (acylating); COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR015590: IPR010061; KEGG: msv:Mesil_1872 methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Methylmalonate-semialdehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. | 0.929 |
| ADU46915.1 | ADU48656.1 | Intca_0366 | Intca_2146 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR012394: IPR016160; KEGG: nda:Ndas_1930 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.929 |
| ADU46915.1 | ADU49369.1 | Intca_0366 | Intca_2870 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814: IPR004632; KEGG: nml:Namu_4960 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; SPTR: 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.818 |
| ADU46915.1 | ackA | Intca_0366 | Intca_0704 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.923 |
| ADU46915.1 | acsA | Intca_0366 | Intca_0516 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.918 |
| ADU47426.1 | ADU47739.1 | Intca_0899 | Intca_1221 | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG1064 Zn-dependent alcohol dehydrogenase; InterPro IPR013154: IPR013149: IPR002328; KEGG: mjl:Mjls_1690 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: Alcohol dehydrogenase, zinc-binding domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.909 |
| ADU47426.1 | ADU48398.1 | Intca_0899 | Intca_1887 | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG1064 Zn-dependent alcohol dehydrogenase; InterPro IPR013154: IPR013149: IPR002328; KEGG: mjl:Mjls_1690 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: Alcohol dehydrogenase, zinc-binding domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. | Zinc-binding alcohol dehydrogenase family protein; COGs: COG1064 Zn-dependent alcohol dehydrogenase; InterPro IPR013154: IPR013149: IPR014187; KEGG: sro:Sros_4103 putative alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: Putative alcohol dehydrogenase; TIGRFAM: zinc-binding alcohol dehydrogenase family protein; PFAM: Alcohol dehydrogenase GroES-like domain; TIGRFAM: zinc-binding alcohol dehydrogenase family protein. | 0.916 |
| ADU47426.1 | ADU48656.1 | Intca_0899 | Intca_2146 | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG1064 Zn-dependent alcohol dehydrogenase; InterPro IPR013154: IPR013149: IPR002328; KEGG: mjl:Mjls_1690 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: Alcohol dehydrogenase, zinc-binding domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR012394: IPR016160; KEGG: nda:Ndas_1930 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.909 |
| ADU47644.1 | ADU46915.1 | Intca_1123 | Intca_0366 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | 0.811 |
| ADU47644.1 | ADU47739.1 | Intca_1123 | Intca_1221 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.917 |
| ADU47644.1 | ADU48271.1 | Intca_1123 | Intca_1759 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | Methylmalonate-semialdehyde dehydrogenase (acylating); COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR015590: IPR010061; KEGG: msv:Mesil_1872 methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Methylmalonate-semialdehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. | 0.919 |
| ADU47644.1 | ADU48656.1 | Intca_1123 | Intca_2146 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR012394: IPR016160; KEGG: nda:Ndas_1930 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 0.917 |
| ADU47644.1 | ADU49369.1 | Intca_1123 | Intca_2870 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814: IPR004632; KEGG: nml:Namu_4960 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; SPTR: 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.900 |
| ADU47644.1 | acsA | Intca_1123 | Intca_0516 | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.811 |
| ADU47739.1 | ADU46915.1 | Intca_1221 | Intca_0366 | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme. | 0.929 |
| ADU47739.1 | ADU47426.1 | Intca_1221 | Intca_0899 | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG1064 Zn-dependent alcohol dehydrogenase; InterPro IPR013154: IPR013149: IPR002328; KEGG: mjl:Mjls_1690 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: Alcohol dehydrogenase, zinc-binding domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. | 0.909 |
| ADU47739.1 | ADU47644.1 | Intca_1221 | Intca_1123 | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | 6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115: IPR002204; KEGG: art:Arth_0273 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 6-phosphogluconate dehydrogenase, NAD-binding; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. | 0.917 |
| ADU47739.1 | ADU48271.1 | Intca_1221 | Intca_1759 | COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590: IPR016160; KEGG: bcv:Bcav_0209 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. | Methylmalonate-semialdehyde dehydrogenase (acylating); COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR015590: IPR010061; KEGG: msv:Mesil_1872 methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Methylmalonate-semialdehyde dehydrogenase; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase. | 0.919 |