STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48790.1DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: kra:Krad_1409 DNA protecting protein DprA; PFAM: SMF family protein; SPTR: DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA. (389 aa)    
Predicted Functional Partners:
ADU48791.1
Mg chelatase, subunit ChlI; COGs: COG0606 ATPase with chaperone activity; InterPro IPR004482: IPR003593: IPR013032: IPR000523; KEGG: kra:Krad_1408 Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; SMART: AAA ATPase; SPTR: Putative uncharacterized protein; TIGRFAM: Mg chelatase, subunit ChlI; PFAM: Magnesium chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein.
 
 0.959
ADU48792.1
Uncharacterized protein family UPF0102; COGs: COG0792 endonuclease distantly related to Holliday junction resolvase; InterPro IPR003509; KEGG: nca:Noca_3248 hypothetical protein; PFAM: Uncharacterised protein family UPF0102; SPTR: UPF0102 protein Noca_3248; PFAM: Uncharacterised protein family UPF0102; TIGRFAM: conserved hypothetical protein TIGR00252.
 
    0.912
ADU47942.1
ComEC/Rec2-related protein; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477; KEGG: kra:Krad_3434 DNA internalization-related competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; SPTR: Putative integral membrane protein; TIGRFAM: ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
 
  
 0.892
ADU49011.1
COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: gob:Gobs_4282 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: Phosphoribosyltransferase; manually curated; PFAM: Phosphoribosyl transferase domain.
 
 
 0.839
ADU47303.1
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932: IPR007895: IPR010822: IPR003594; KEGG: gob:Gobs_0116 multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E; MASE1 domain protein; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E (SpoIIE); MASE1.
 
    0.780
ADU48104.1
Peptidase A24A prepilin type IV; InterPro IPR000045; KEGG: kra:Krad_3020 peptidase A24A domain protein; PFAM: peptidase A24A prepilin type IV; SPTR: Putative uncharacterized protein; PFAM: Type IV leader peptidase family.
  
  
 0.752
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
    0.638
ADU49059.1
ATP-dependent DNA helicase, Rep family; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121: IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1179 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: Putative ATP-dependent DNA helicase; manually curated; PFAM: HRDC domain; UvrD/REP helicase.
 
  
 0.635
ADU48793.1
Protein of unknown function DUF2469; InterPro IPR019592; KEGG: sen:SACE_6046 hypothetical protein; PFAM: Protein of unknown function DUF2469; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2469).
       0.628
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.616
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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