STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnhBRibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (264 aa)    
Predicted Functional Partners:
ADU46564.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.944
ADU48795.1
Signal peptidase I; InterPro IPR000223: IPR019758: IPR019759; KEGG: kra:Krad_1404 signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; SPTR: Putative signal peptidase; TIGRFAM: signal peptidase I; PFAM: Peptidase S26; Peptidase S24-like; TIGRFAM: signal peptidase I, bacterial type; Belongs to the peptidase S26 family.
 
    0.928
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
    0.899
ADU48793.1
Protein of unknown function DUF2469; InterPro IPR019592; KEGG: sen:SACE_6046 hypothetical protein; PFAM: Protein of unknown function DUF2469; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2469).
       0.837
ADU48796.1
Signal peptidase I; InterPro IPR000223: IPR019758: IPR019759; KEGG: kra:Krad_1403 signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; PRIAM: Signal peptidase I; SPTR: Signal peptidase I; TIGRFAM: signal peptidase I; manually curated; PFAM: Peptidase S24-like; TIGRFAM: signal peptidase I, bacterial type; Belongs to the peptidase S26 family.
  
    0.831
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.796
ADU48560.1
COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: gob:Gobs_3460 phosphoglycerate mutase; PFAM: ribonuclease H; SPTR: Bifunctional RNase H/acid phosphatase; PFAM: RNase H.
   
 
 0.791
ADU46988.1
COGs: COG3569 Topoisomerase IB; InterPro IPR001631; KEGG: amd:AMED_4291 DNA topoisomerase IB; SPTR: Putative uncharacterized protein; PFAM: Eukaryotic DNA topoisomerase I, catalytic core.
    
 
 0.715
rplS
LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
 
   
 0.714
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.709
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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