STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU48807.1COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002332: IPR002187; KEGG: ace:Acel_1565 nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Putative nitrogen regulatory protein P-II; PFAM: Nitrogen regulatory protein P-II. (112 aa)    
Predicted Functional Partners:
ADU48808.1
Ammonium transporter; COGs: COG0004 Ammonia permease; InterPro IPR001905: IPR018047; KEGG: msm:MSMEG_2425 ammonium transporter; PFAM: ammonium transporter; SPTR: Low affinity ammonium uptake protein; TIGRFAM: ammonium transporter; PFAM: Ammonium Transporter Family; TIGRFAM: ammonium transporter; TC 1.A.11.
 
 0.999
glnD
UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
 
 0.996
argB
N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
  
 
 
 0.900
ADU47620.1
Hypothetical protein; COGs: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components; InterPro IPR001969; KEGG: dsh:Dshi_2543 putative binding protein; SPTR: ABC transporter, periplasmic binding protein; PFAM: NMT1/THI5 like.
   
 
 0.812
ADU48539.1
COGs: COG0174 Glutamine synthetase; InterPro IPR008147: IPR008146: IPR004809; KEGG: kra:Krad_3291 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
 
 
 0.788
ADU48157.1
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR017932: IPR000583: IPR006982: IPR002932: IPR 002489; KEGG: kfl:Kfla_3074 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Putative glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
 
  
 0.771
ADU48006.1
ADP-ribosylation/Crystallin J1; COGs: COG1397 ADP-ribosylglycohydrolase; InterPro IPR005502: IPR000387; KEGG: ske:Sked_03580 ADP-ribosylglycohydrolase; PFAM: ADP-ribosylation/Crystallin J1; SPTR: Putative ribosylglycohydrolase; PFAM: ADP-ribosylglycohydrolase.
   
 
 0.769
ADU48543.1
COGs: COG0174 Glutamine synthetase; InterPro IPR008147: IPR008146; KEGG: tbi:Tbis_1258 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Glutamine synthetase type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
  
 
 0.735
ADU46835.1
KEGG: ecx:EcHS_A2423 hypothetical protein; SPTR: Putative uncharacterized protein.
    
 
 0.706
ADU48076.1
KEGG: sen:SACE_5253 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated.
    
 
 0.706
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.