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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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smcCondensin subunit Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1197 aa)    
Predicted Functional Partners:
ADU48351.1
Condensin subunit ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
 
 
 0.965
ADU48350.1
Condensin subunit ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
 
 
 0.897
ADU49059.1
ATP-dependent DNA helicase, Rep family; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121: IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1179 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: Putative ATP-dependent DNA helicase; manually curated; PFAM: HRDC domain; UvrD/REP helicase.
 
 
 0.812
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
 
   0.782
ADU47965.1
InterPro IPR013494; KEGG: sma:SAV_7223 hypothetical protein; PFAM: Conserved hypothetical protein CHP02678; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2398); TIGRFAM: conserved hypothetical protein TIGR02678.
   
   0.742
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 
 0.560
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.560
ffh
Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
   0.557
ADU48460.1
DNA topoisomerase IV subunit B; COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR001241: IPR000565: IPR003594: IPR013506: IPR 006171: IPR002288: IPR018522; KEGG: ach:Achl_1613 DNA topoisomerase IV subunit B; PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; TOPRIM domain-containing protein; DNA gyrase subunit B domain protein; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: DNA gyrase subunit B; PFAM: Toprim [...]
  
 
 0.553
ADU48807.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002332: IPR002187; KEGG: ace:Acel_1565 nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Putative nitrogen regulatory protein P-II; PFAM: Nitrogen regulatory protein P-II.
     
 0.530
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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