Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
nucSProtein of unknown function DUF91; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (231 aa)    
Predicted Functional Partners:
whiB-4
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.736
ADU48927.1
KEGG: bcv:Bcav_1315 hypothetical protein; SPTR: Putative ATP/GTP-binding protein.
 
   
 0.693
ADU48328.1
Regulatory protein MerR; InterPro IPR000551; KEGG: aau:AAur_1684 hypothetical protein; SMART: regulatory protein MerR; SPTR: Putative uncharacterized protein.
  
     0.684
whiB-5
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.676
ADU49365.1
COGs: COG1820 N-acetylglucosamine-6-phosphate deacetylase; InterPro IPR006680: IPR003764; KEGG: tfu:Tfu_2473 N-acetylglucosamine 6-phosphate deacetylase; PFAM: amidohydrolase; PRIAM: N-acetylglucosamine-6-phosphate deacetylase; SPTR: N-acetylglucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; PFAM: Amidohydrolase family; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase.
      0.652
ADU47826.1
KEGG: aau:AAur_2578 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3039).
  
     0.647
ADU46564.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 
 0.636
ADU47827.1
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935: IPR014001: IPR014021; KEGG: kse:Ksed_10520 DNA/RNA helicase, superfamily II; PFAM: type III restriction protein res subunit; SMART: DEAD-like helicase; SPTR: Putative uncharacterized protein; manually curated; PFAM: Type III restriction enzyme, res subunit.
 
     0.625
ADU46567.1
Protein of unknown function DUF721; COGs: COG5512 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives; InterPro IPR007922; KEGG: kra:Krad_0005 protein of unknown function DUF721; PFAM: protein of unknown function DUF721; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF721).
  
   
 0.611
ADU48928.1
COGs: COG1250 3-hydroxyacyl-CoA dehydrogenase; InterPro IPR006176: IPR006108; KEGG: kfl:Kfla_5009 3-hydroxyacyl-CoA dehydrogenase., 3-hydroxybutyryl-CoA dehydrogenase; PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; PRIAM: 3-hydroxybutyryl-CoA dehydrogenase., 3-hydroxybutyryl-CoA epimerase; SPTR: Putative 3-hydroxyacyl-CoA dehydrogenase; PFAM: 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain.
       0.591
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (6%) [HD]