STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCProtein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (427 aa)    
Predicted Functional Partners:
ADU48977.1
COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232; KEGG: gob:Gobs_1558 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Asparagine synthase; TIGRFAM: conserved hypothetical protein TIGR00268.
  
 0.930
ADU48978.1
1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: cef:CE2360 putative carboxylase; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: Phosphoribosylaminoimidazole carboxylase catalytic subunit; PFAM: AIR carboxylase.
 
  
 0.923
ADU48972.1
Protein of unknown function DUF2088; COGs: COG3875 conserved hypothetical protein; InterPro IPR018657; KEGG: fre:Franean1_3196 hypothetical protein; PFAM: Protein of unknown function DUF2088; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2088).
 
  
 0.864
cbiM
Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
  
    0.510
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
       0.435
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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