Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADU49018.1Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase; InterPro IPR019490: IPR006162; KEGG: kra:Krad_3839 putative transcriptional regulator, RpiR family; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like; SPTR: Putative uncharacterized protein; PFAM: Bacterial phospho-glucose isomerase C-terminal region. (379 aa)    
Predicted Functional Partners:
ADU49020.1
COGs: COG1109 Phosphomannomutase; InterProIPR005841: IPR005844: IPR005845: IPR005846: IPR 005843; KEGG: kra:Krad_3841 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Putative phosphomannomutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomuta [...]
  
 
  0.981
ADU47469.1
Glutamine--fructose-6-phosphate transaminase; COGs: COG0449 Glucosamine 6-phosphate synthetase contains amidotransferase and phosphosugar isomerase domains; InterPro IPR001347; KEGG: kra:Krad_0771 glutamine--fructose-6-phosphate transaminase (isomerizing); PFAM: sugar isomerase (SIS); PRIAM: Glutamine--fructose-6-phosphate transaminase (isomerizing); SPTR: Glutamine--fructose-6-phosphate transaminase (Isomerizing); PFAM: SIS domain.
  
 
 0.922
glmS
Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
  
 
 0.922
ADU49196.1
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611: IPR002173; KEGG: tpr:Tpau_0525 PfkB domain protein; PFAM: PfkB domain protein; SPTR: Putative uncharacterized protein; PFAM: pfkB family carbohydrate kinase.
  
 
 0.919
ADU48483.1
Glucokinase; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600: IPR004654; KEGG: sco:SCO6260 sugar kinase; PFAM: ROK family protein; SPTR: Putative sugar kinase; TIGRFAM: glucokinase, ROK family; PFAM: ROK family; TIGRFAM: ROK family protein (putative glucokinase).
 
  
  0.916
ADU46967.1
Glycoside hydrolase family 4; COGs: COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase family 4 of glycosyl hydrolase; InterPro IPR001088: IPR019802; KEGG: sgr:SGR_1058 putative 6-phospho-beta-glucosidase; PFAM: glycoside hydrolase family 4; SPTR: Putative 6-phospho-beta-glucosidase; PFAM: Family 4 glycosyl hydrolase; Family 4 glycosyl hydrolase C-terminal domain.
    
  0.911
pfkA
Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
    
 0.908
ADU47742.1
Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005844: IPR005845: IPR005846: IPR005843: IPR 016066; KEGG: kse:Ksed_08160 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Putative phosphomannomutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutas [...]
  
 
  0.906
ADU47476.1
ROK family protein; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600: IPR002328; KEGG: bcv:Bcav_3770 ROK family protein; PFAM: ROK family protein; SPTR: ROK family protein; PFAM: ROK family.
    
  0.905
ADU48548.1
Polyphosphate glucokinase; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: kse:Ksed_12150 polyphosphate glucokinase; PFAM: ROK family protein; SPTR: Polyphosphate glucokinase/transcriptional regulator; PFAM: ROK family.
    
  0.905
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (26%) [HD]