| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADU46564.1 | ADU46798.1 | Intca_0002 | Intca_0241 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | 0.408 |
| ADU46564.1 | ADU47578.1 | Intca_0002 | Intca_1055 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212: IPR014016: IPR014017: IPR005751; KEGG: kse:Ksed_07720 ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; SPTR: Putative ATP-dependent DNA helicase II; TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | 0.689 |
| ADU46564.1 | ADU49059.1 | Intca_0002 | Intca_2553 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase, Rep family; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121: IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1179 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: Putative ATP-dependent DNA helicase; manually curated; PFAM: HRDC domain; UvrD/REP helicase. | 0.963 |
| ADU46564.1 | ADU49063.1 | Intca_0002 | Intca_2557 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1172 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: Putative DNA helicase; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. | 0.717 |
| ADU46564.1 | ADU49064.1 | Intca_0002 | Intca_2558 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1171 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: Putative ATP-dependent DNA helicase; PFAM: UvrD/REP helicase. | 0.681 |
| ADU46564.1 | ADU50023.1 | Intca_0002 | Intca_3550 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ERCC4 domain protein; InterPro IPR006166; KEGG: nca:Noca_3806 ERCC4 domain-containing protein; PFAM: ERCC4 domain protein; SPTR: ERCC4 domain protein; PFAM: Lsr2. | 0.890 |
| ADU46564.1 | polA | Intca_0002 | Intca_1656 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.984 |
| ADU46564.1 | recA | Intca_0002 | Intca_2170 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.939 |
| ADU46564.1 | sbcD | Intca_0002 | Intca_0242 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.433 |
| ADU46564.1 | topA | Intca_0002 | Intca_0553 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.720 |
| ADU46798.1 | ADU46564.1 | Intca_0241 | Intca_0002 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.408 |
| ADU46798.1 | ADU47578.1 | Intca_0241 | Intca_1055 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212: IPR014016: IPR014017: IPR005751; KEGG: kse:Ksed_07720 ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; SPTR: Putative ATP-dependent DNA helicase II; TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | 0.400 |
| ADU46798.1 | ADU49059.1 | Intca_0241 | Intca_2553 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | ATP-dependent DNA helicase, Rep family; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121: IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1179 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: Putative ATP-dependent DNA helicase; manually curated; PFAM: HRDC domain; UvrD/REP helicase. | 0.963 |
| ADU46798.1 | ADU49063.1 | Intca_0241 | Intca_2557 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1172 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: Putative DNA helicase; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. | 0.455 |
| ADU46798.1 | ADU49064.1 | Intca_0241 | Intca_2558 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212; KEGG: kra:Krad_1171 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: Putative ATP-dependent DNA helicase; PFAM: UvrD/REP helicase. | 0.455 |
| ADU46798.1 | ADU50023.1 | Intca_0241 | Intca_3550 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | ERCC4 domain protein; InterPro IPR006166; KEGG: nca:Noca_3806 ERCC4 domain-containing protein; PFAM: ERCC4 domain protein; SPTR: ERCC4 domain protein; PFAM: Lsr2. | 0.525 |
| ADU46798.1 | polA | Intca_0241 | Intca_1656 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.925 |
| ADU46798.1 | recA | Intca_0241 | Intca_2170 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.886 |
| ADU46798.1 | sbcD | Intca_0241 | Intca_0242 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.999 |
| ADU46798.1 | topA | Intca_0241 | Intca_0553 | Putative exonuclease; COGs: COG0419 ATPase involved in DNA repair; KEGG: cfl:Cfla_0124 putative exonuclease; SPTR: Putative exonuclease; TIGRFAM: exonuclease SbcC. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.848 |
