STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49066.1UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR001763: IPR000594: IPR007901; KEGG: ace:Acel_1777 molybdopterin biosynthesis-like protein MoeZ; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: UBA/THIF-type NAD/FAD binding protein; PFAM: MoeZ/MoeB domain; Rhodanese-like domain; ThiF family. (392 aa)    
Predicted Functional Partners:
ADU48874.1
thiamineS protein; InterPro IPR003749; KEGG: aau:AAur_4051 ThiS family protein; PFAM: thiamineS protein; SPTR: ThiS family protein; PFAM: ThiS family.
 
 0.985
ADU49443.1
thiamineS protein; InterPro IPR003749; KEGG: mmi:MMAR_4664 molybdenum cofactor biosynthesis protein D 2 MoaD2; PFAM: thiamineS protein; SPTR: Putative molybdopterin converting factor; PFAM: ThiS family.
  
 0.983
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.977
ADU48501.1
COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192; KEGG: stp:Strop_3301 aminotransferase, class V; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Putative aminotransferase; PFAM: Aminotransferase class-V.
   
 0.974
ADU48897.1
COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR016454: IPR000192; KEGG: cai:Caci_1302 aminotransferase class V; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Putative uncharacterized protein; PFAM: Aminotransferase class-V.
   
 0.974
ADU47918.1
Thiamine biosynthesis protein ThiS; InterPro IPR010035: IPR003749; KEGG: mmi:MMAR_0719 thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
  
 
 0.958
ADU49048.1
COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR003448; KEGG: scb:SCAB_30561 putative MoaE-like protein; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: Molybdopterin biosynthesis protein E; PFAM: MoaE protein.
 
 0.951
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.883
ADU47915.1
COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399: IPR013749; KEGG: nca:Noca_3401 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; PRIAM: Phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
 
  
 0.845
ADU49065.1
Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding protein; COGs: COG3695 methylated DNA-protein cysteine methyltransferase; InterPro IPR014048: IPR004360; KEGG: cfl:Cfla_0254 glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain.
       0.830
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.