STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49092.1HpcH/HpaI aldolase; COGs: COG2301 Citrate lyase beta subunit; InterPro IPR011206: IPR005000; KEGG: amd:AMED_0079 citrate lyase subunit beta; PFAM: HpcH/HpaI aldolase; SPTR: Citrate lyase, beta subunit, putative; PFAM: HpcH/HpaI aldolase/citrate lyase family; Belongs to the HpcH/HpaI aldolase family. (355 aa)    
Predicted Functional Partners:
ADU47746.1
Biotin carboxyl carrier protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR005481: IPR005479: IPR005482: IPR000089: IPR 001882: IPR011761: IPR011764; KEGG: kse:Ksed_08190 acetyl/propionyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: Putative acyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-te [...]
  
 
 0.920
ADU47357.1
COGs: COG2225 Malate synthase; InterPro IPR011076: IPR006252: IPR019830; KEGG: kfl:Kfla_0722 malate synthase A; PFAM: Malate synthase family protein; PRIAM: Malate synthase; SPTR: Malate synthase; TIGRFAM: malate synthase A; PFAM: Malate synthase; TIGRFAM: malate synthase A; Belongs to the malate synthase family.
    
 0.912
ADU47762.1
COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR000022: IPR011762: IPR011763: IPR000438; KEGG: kfl:Kfla_1439 carboxyl transferase; PFAM: carboxyl transferase; SPTR: Propionyl-CoA carboxylase complex B subunit; PFAM: Carboxyl transferase domain.
  
 
 0.909
ADU46915.1
COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: cai:Caci_4507 acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme.
    
 0.907
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
    
 0.907
ADU47249.1
Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.906
ADU46611.1
COGs: COG0247 Fe-S oxidoreductase; InterPro IPR004017: IPR012257: IPR017900: IPR017896; KEGG: gob:Gobs_0251 protein of unknown function DUF224 cysteine-rich region domain protein; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; SPTR: Putative uncharacterized protein; PFAM: Cysteine-rich domain.
     
  0.900
ADU46612.1
FAD linked oxidase domain protein; COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094: IPR004113: IPR016166; KEGG: sen:SACE_4261 (S)-2-hydroxy-acid oxidase, subunit D; PFAM: FAD linked oxidase domain protein; SPTR: (S)-2-hydroxy-acid oxidase, subunit D; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD.
     
  0.900
ADU47358.1
D-lactate dehydrogenase (cytochrome); COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR016166: IPR006094: IPR004113; KEGG: sen:SACE_6366 glycolate oxidase subunit; PFAM: FAD linked oxidase domain protein; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: Glycolate oxidase subunit; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD.
     
  0.900
ADU47359.1
FAD linked oxidase domain protein; COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR016166: IPR006094: IPR004113; KEGG: tcu:Tcur_3272 FAD linked oxidase domain protein; PFAM: FAD linked oxidase domain protein; SPTR: FAD linked oxidase domain protein; PFAM: FAD binding domain.
     
  0.900
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.