STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU49308.1Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR000595: IPR003594: IPR005467: IPR004358; KEGG: rha:RHA1_ro04003 sensor kinase, two-component system; PFAM: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SMART: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SPTR: Histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (468 aa)    
Predicted Functional Partners:
ADU46986.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467: IPR001789: IPR000014: IPR000700: IPR 005561: IPR013656: IPR003661: IPR003594: IPR013767: IPR004358; KEGG: ami:Amir_3954 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; response regulator receiver; PAS fold domain protein; ANTAR domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Multi [...]
 
 0.991
ADU49309.1
Response regulator receiver protein; COGs: COG0492 Thioredoxin reductase; InterPro IPR001789: IPR000103: IPR013027; KEGG: rer:RER_40230 two-component system thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Response regulator receiver domain.
 
 
 0.991
ADU49390.1
KEGG: pjd:Pjdr2_2870 hypothetical protein; SPTR: Putative uncharacterized protein.
 
 
 0.878
ADU47485.1
Putative hydrolase and adenylate/guanylate cyclase; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR000073: IPR001054; KEGG: mav:MAV_5228 hydrolase, alpha/beta hydrolase fold family protein; PFAM: alpha/beta hydrolase fold; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Hydrolase, alpha/beta hydrolase fold family protein; PFAM: Adenylate and Guanylate cyclase catalytic domain; alpha/beta hydrolase fold.
 
 0.869
ADU48391.1
InterPro IPR001440: IPR019734: IPR013026; KEGG: cyp:PCC8801_1300 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; SMART: Tetratricopeptide repeat; SPTR: TPR repeat-containing protein; PFAM: Tetratricopeptide repeat.
 
 
 0.868
ADU46835.1
KEGG: ecx:EcHS_A2423 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 0.836
ADU48076.1
KEGG: sen:SACE_5253 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated.
   
 0.836
ADU47551.1
Hypothetical protein; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; KEGG: tcu:Tcur_2746 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: 6-pyruvoyl tetrahydropterin synthase.
    
  0.773
ADU48157.1
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR017932: IPR000583: IPR006982: IPR002932: IPR 002489; KEGG: kfl:Kfla_3074 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Putative glutamate synthase (NADPH) large subunit; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
  
  
 0.739
ADU47303.1
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932: IPR007895: IPR010822: IPR003594; KEGG: gob:Gobs_0116 multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E; MASE1 domain protein; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Multi-sensor signal transduction histidine kinase; PFAM: Stage II sporulation protein E (SpoIIE); MASE1.
  
 0.728
Your Current Organism:
Intrasporangium calvum
NCBI taxonomy Id: 710696
Other names: I. calvum DSM 43043, Intrasporangium calvum DSM 43043, Intrasporangium calvum IFO 12989, Intrasporangium calvum NBRC 12989, Intrasporangium calvum str. DSM 43043, Intrasporangium calvum strain DSM 43043
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