| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADU48135.1 | ADU48731.1 | Intca_1622 | Intca_2222 | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: sgr:SGR_6090 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Putative riboflavin synthase alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR004821: IPR002606: IPR015864: IPR015865; KEGG: ske:Sked_23420 FMN adenylyltransferase/riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin kinase/ FMN adenyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; manually curated; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | 0.927 |
| ADU48135.1 | ADU49380.1 | Intca_1622 | Intca_2881 | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: sgr:SGR_6090 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Putative riboflavin synthase alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | 0.900 |
| ADU48268.1 | ADU49380.1 | Intca_1755 | Intca_2881 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | 0.439 |
| ADU48321.1 | ADU48731.1 | Intca_1809 | Intca_2222 | NADPH-dependent FMN reductase; COGs: COG0431 flavoprotein; InterPro IPR005025; KEGG: gob:Gobs_2153 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; TIGRFAM: FMN reductase, MsuE subfamily. | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR004821: IPR002606: IPR015864: IPR015865; KEGG: ske:Sked_23420 FMN adenylyltransferase/riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin kinase/ FMN adenyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; manually curated; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | 0.909 |
| ADU48321.1 | ADU49380.1 | Intca_1809 | Intca_2881 | NADPH-dependent FMN reductase; COGs: COG0431 flavoprotein; InterPro IPR005025; KEGG: gob:Gobs_2153 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; TIGRFAM: FMN reductase, MsuE subfamily. | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | 0.900 |
| ADU48731.1 | ADU48135.1 | Intca_2222 | Intca_1622 | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR004821: IPR002606: IPR015864: IPR015865; KEGG: ske:Sked_23420 FMN adenylyltransferase/riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin kinase/ FMN adenyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; manually curated; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: sgr:SGR_6090 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Putative riboflavin synthase alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | 0.927 |
| ADU48731.1 | ADU48321.1 | Intca_2222 | Intca_1809 | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR004821: IPR002606: IPR015864: IPR015865; KEGG: ske:Sked_23420 FMN adenylyltransferase/riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin kinase/ FMN adenyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; manually curated; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | NADPH-dependent FMN reductase; COGs: COG0431 flavoprotein; InterPro IPR005025; KEGG: gob:Gobs_2153 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; TIGRFAM: FMN reductase, MsuE subfamily. | 0.909 |
| ADU48731.1 | ADU49380.1 | Intca_2222 | Intca_2881 | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR004821: IPR002606: IPR015864: IPR015865; KEGG: ske:Sked_23420 FMN adenylyltransferase/riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin kinase/ FMN adenyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; manually curated; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | 0.906 |
| ADU49380.1 | ADU48135.1 | Intca_2881 | Intca_1622 | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: sgr:SGR_6090 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Putative riboflavin synthase alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. | 0.900 |
| ADU49380.1 | ADU48268.1 | Intca_2881 | Intca_1755 | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.439 |
| ADU49380.1 | ADU48321.1 | Intca_2881 | Intca_1809 | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | NADPH-dependent FMN reductase; COGs: COG0431 flavoprotein; InterPro IPR005025; KEGG: gob:Gobs_2153 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; TIGRFAM: FMN reductase, MsuE subfamily. | 0.900 |
| ADU49380.1 | ADU48731.1 | Intca_2881 | Intca_2222 | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | Riboflavin kinase; COGs: COG0196 FAD synthase; InterPro IPR004821: IPR002606: IPR015864: IPR015865; KEGG: ske:Sked_23420 FMN adenylyltransferase/riboflavin kinase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin kinase/ FMN adenyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; manually curated; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. | 0.906 |
| ADU49380.1 | ADU49381.1 | Intca_2881 | Intca_2882 | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | InterPro IPR011701; KEGG: ade:Adeh_0552 major facilitator transporter; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1 transporter; PFAM: Major Facilitator Superfamily. | 0.675 |
| ADU49380.1 | ADU49382.1 | Intca_2881 | Intca_2883 | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR017439: IPR002933: IPR011650: IPR010168; KEGG: mcu:HMPREF0573_11409 amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: N-acetyldiaminopimelate deacetylase; SPTR: Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. | 0.675 |
| ADU49380.1 | ADU49383.1 | Intca_2881 | Intca_2884 | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | Transcriptional regulator, AsnC family; COGs: COG1522 Transcriptional regulators; InterPro IPR019888: IPR019887; KEGG: rer:RER_25740 AsnC family transcriptional regulator; PFAM: Transcription regulator AsnC-type-like; SMART: Transcription regulator AsnC-type; SPTR: Putative AsnC family transcriptional regulator; PFAM: AsnC family. | 0.470 |
| ADU49381.1 | ADU49380.1 | Intca_2882 | Intca_2881 | InterPro IPR011701; KEGG: ade:Adeh_0552 major facilitator transporter; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1 transporter; PFAM: Major Facilitator Superfamily. | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | 0.675 |
| ADU49381.1 | ADU49382.1 | Intca_2882 | Intca_2883 | InterPro IPR011701; KEGG: ade:Adeh_0552 major facilitator transporter; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1 transporter; PFAM: Major Facilitator Superfamily. | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR017439: IPR002933: IPR011650: IPR010168; KEGG: mcu:HMPREF0573_11409 amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: N-acetyldiaminopimelate deacetylase; SPTR: Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. | 0.866 |
| ADU49381.1 | ADU49383.1 | Intca_2882 | Intca_2884 | InterPro IPR011701; KEGG: ade:Adeh_0552 major facilitator transporter; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1 transporter; PFAM: Major Facilitator Superfamily. | Transcriptional regulator, AsnC family; COGs: COG1522 Transcriptional regulators; InterPro IPR019888: IPR019887; KEGG: rer:RER_25740 AsnC family transcriptional regulator; PFAM: Transcription regulator AsnC-type-like; SMART: Transcription regulator AsnC-type; SPTR: Putative AsnC family transcriptional regulator; PFAM: AsnC family. | 0.531 |
| ADU49382.1 | ADU49380.1 | Intca_2883 | Intca_2881 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR017439: IPR002933: IPR011650: IPR010168; KEGG: mcu:HMPREF0573_11409 amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: N-acetyldiaminopimelate deacetylase; SPTR: Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. | Metallophosphoesterase; InterPro IPR004843; KEGG: sus:Acid_0081 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase. | 0.675 |
| ADU49382.1 | ADU49381.1 | Intca_2883 | Intca_2882 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR017439: IPR002933: IPR011650: IPR010168; KEGG: mcu:HMPREF0573_11409 amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: N-acetyldiaminopimelate deacetylase; SPTR: Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. | InterPro IPR011701; KEGG: ade:Adeh_0552 major facilitator transporter; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1 transporter; PFAM: Major Facilitator Superfamily. | 0.866 |